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Myc orchestrates a regulatory network required for the establishment and maintenance of pluripotency.

机译：Myc协调建立和维护多能性所需的监管网络。

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摘要

Pluripotent stem cells (PSCs) are maintained by a complex regulatory network orchestrated by transcription factors, epigenetic modifiers and non-coding RNAs. Central to this regulatory network is the Myc family of transcription factors. Defining roles for Myc in PSCs has been problematic but recently, a number of reports have provided insight into this question. An emerging picture now places Myc as a key regulator of the cell cycle, genomic maintenance and general metabolic activity in PSCs through its ability to directly regulate large numbers of target genes and more indirectly through control of microRNAs. One of Myc's main roles is to repress the activity of genes required for differentiation such as the endoderm master regulator, GATA6. The general mechanism by which Myc activates target genes is well understood but a remaining major challenge is to understand how it represses gene activity. Here we discuss potential mechanisms for how Myc establishes and maintains the pluripotent state and incorporate proteomics data that supports a model where Myc acts as part of a regulatory network with epigenetic modifiers.
机译：多能干细胞（PSC）通过由转录因子，表观遗传修饰剂和非编码RNA编排的复杂调控网络来维持。该调节网络的核心是Myc转录因子家族。定义Myc在PSC中的角色一直存在问题，但是最近，许多报告提供了对该问题的见解。 Myc通过直接调节大量靶基因的能力，更间接地通过控制microRNA的能力，将其作为PSC中细胞周期，基因组维持和一般代谢活性的关键调节剂。 Myc的主要作用之一是抑制分化所需的基因（例如内胚层主调控因子GATA6）的活性。 Myc激活靶基因的一般机制已广为人知，但剩下的主要挑战是了解它如何抑制基因活性。在这里，我们讨论了Myc如何建立和维持多能状态并整合蛋白质组学数据的潜在机制，该数据支持Myc充当表观遗传修饰子调控网络的一部分的模型。

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