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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >The size of the metastatic lymph node is an independent prognostic factor for the patients with cervical cancer treated by definitive radiotherapy
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The size of the metastatic lymph node is an independent prognostic factor for the patients with cervical cancer treated by definitive radiotherapy

机译：对于确定性放疗治疗的宫颈癌患者，转移性淋巴结的大小是一个独立的预后因素

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摘要

Background and purpose Lymph node (LN) metastasis is a well-known prognostic factor of the cervical cancer. In the current study, the size of metastatic LN was evaluated for its significance in the patients treated with definitive radiotherapy. Materials and methods LN metastasis was evaluated for the 268 consecutive patients. The short-axis diameters of the largest LN were measured on magnetic resonance images for the 155 patients with LN metastasis. All the patients were classified into three groups: the negative lymphadenopathy (group N), the small (<15 mm) lymphadenopathy (group SP), and the large (≥15 mm) lymphadenopathy (group LP). Results Patients in the group LP showed significantly lower survival rates than the groups N and SP (5-year overall survival rates of 89%, 82%, and 58%, for groups N, SP, and LP, respectively, P < 0.001; 5-year disease-free survival rates of 80%, 67%, and 50%, respectively, P < 0.001). Regarding the pattern of failure, patients in the group LP showed inferior regional control rates and higher distant metastasis. Conclusion The current study shows that the patients with large metastatic LNs are at increased risk of dying from early distant metastasis with substantial number of combined regional failures. Adoption of more effective systemic treatment as well as high radiotherapy dose for LNs may improve cure rates for these patients.
机译：背景和目的淋巴结转移是宫颈癌的一个众所周知的预后因素。在当前的研究中，评估了转移性LN的大小在确定性放疗患者中的意义。材料和方法评价了268例连续患者的LN转移情况。在155例LN转移患者的磁共振图像上测量了最大LN的短轴直径。将所有患者分为三组：阴性淋巴结肿大（N组），小淋巴结肿大（<15 mm）（SP组）和大淋巴结肿大（≥15mm）（LP组）。结果LP组的患者生存率显着低于N和SP组（N，SP和LP组的5年总生存率分别为89％，82％和58％，P <0.001; 5年无病生存率分别为80％，67％和50％，P <0.001）。关于失败的模式，LP组的患者显示出较差的区域控制率和较高的远处转移。结论当前的研究表明，具有大转移性LN的患者死于早期远处转移的危险性增加，并伴有大量合并的区域衰竭。对LN采取更有效的全身治疗以及高放疗剂量可以提高这些患者的治愈率。

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