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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Effect of age on radiation-induced early changes of rat rectum. A histological time sequence.
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Effect of age on radiation-induced early changes of rat rectum. A histological time sequence.

机译：年龄对辐射诱发的大鼠直肠早期变化的影响。组织学时间序列。

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BACKGROUND AND PURPOSE: Radiation treatment of the elderly (> 75 years) is often modified due to an assumed decrease in normal tissue tolerance in this age group. Since more radiobiological data concerning normal tissue toxicity as a function of age are needed, a histological study of age-related radiation changes of the rectum was performed. MATERIALS AND METHODS: The rectum of young and old female Wistar rats (12 and 78 weeks, respectively) was irradiated with single doses of 22 and 39 Gy. The field size was 1.5 x 2.0 cm. The animals were sacrificed at 1, 2, 4 and 10 weeks after treatment. To evaluate radiation damage, 12 histological parameters were scored in four areas of the rectum. A total radiation injury score was calculated. The number of proliferative epithelial cells was evaluated by 5-bromo-2'-deoxyuridine labeling. RESULTS: Some age-related histological differences were observed; especially, the incidence of ulceration and vascular occlusion was higher in the older group. In the low dose group of the older animals, 60% showed ulceration, which was 0% for the young low dose animals. Severe vascular changes occurred early and were more extensive in older animals (4 weeks) than in the younger group (10 weeks). In the area adjacent to the treatment field, cell proliferation increased significantly in older rats at 1 week after 22 Gy, which did not occur in the young group. CONCLUSIONS: Discrete radiation-induced histological differences were observed between the rectum of young and old Wistar rats, especially in the development of ulceration and vascular changes. Although the survival of these Wistar rats in earlier studies was not affected by age, the impact of the observed histological differences for their importance in the long-term is currently being investigated.
机译：背景与目的：由于假定该年龄组正常组织耐受性下降，经常对老年人（> 75岁）进行放射治疗。由于需要更多有关正常组织毒性随年龄变化的放射生物学数据，因此进行了与年龄有关的直肠放射线变化的组织学研究。材料与方法：用22和39 Gy的单剂量辐照幼龄和成年雌性Wistar大鼠的直肠（分别为12周和78周）。视场大小为1.5 x 2.0厘米。在处理后1、2、4和10周处死动物。为了评估放射损伤，在直肠的四个区域对12个组织学参数进行了评分。计算总的放射损伤分数。通过5-溴-2'-脱氧尿苷标记评估增殖上皮细胞的数目。结果：观察到一些与年龄相关的组织学差异。特别是老年组溃疡和血管闭塞的发生率更高。在年长动物的低剂量组中，有60％的人表现出溃疡，对于年幼的低剂量动物，则为0％。较早的动物（10周）较早的动物（4周）中发生了严重的血管变化，且范围更广。在邻近治疗区域的区域，在22 Gy后1周，老年大鼠的细胞增殖显着增加，而年轻组则没有。结论：Wistar大鼠和老年大鼠的直肠之间存在离散的辐射诱导的组织学差异，尤其是在溃疡的发展和血管的变化方面。尽管这些Wistar大鼠在早期研究中的存活率不受年龄的影响，但目前正在研究观察到的组织学差异对其长期重要性的影响。

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