MicroRNA-dependent regulation of the microenvironment and the epithelial stromal cell interactions in the mouse mammary gland.

Ucar A; Vafaizadeh V; Chowdhury K; Groner B

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MicroRNA-dependent regulation of the microenvironment and the epithelial stromal cell interactions in the mouse mammary gland.

机译：小鼠乳腺中微环境和上皮基质细胞相互作用的MicroRNA依赖性调节。

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MicroRNAs are endogenous small RNAs regulating the expression of their target genes on the post-transcriptional level. Up to now, loss-of-function mutants were generated in mice for only a few individual microRNAs in order to elucidate their functions in vivo.These .studies showed that these individual microRNAs play important roles in both.the cardiovascular and immune systems. We have recently shown that the miR-212/132 family has an indispensable function in the development of mammary gland in mice. The epithelial-stromal cell communications, necessary for the pubertal development of mammary gland, is regulated by the miR-212/132 family. This represents the first example for a microRNA function in a developmental process propagated through the organ microenvironment

机译：MicroRNA是内源性小RNA，在转录后水平上调节其靶基因的表达。迄今为止，为了在体内阐明其功能，仅在小鼠中产生了功能缺失的突变体，以阐明它们的体内功能。这些研究表明，这些独立的microRNA在心血管和免疫系统中均起着重要作用。我们最近显示，miR-212 / 132家族在小鼠乳腺发育中具有不可或缺的功能。乳腺的青春期发育所必需的上皮-间质细胞通讯受miR-212 / 132家族调节。这是通过器官微环境传播的发育过程中microRNA功能的第一个例子

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《Cell cycle》 |2011年第4期|共3页
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Ucar A; Vafaizadeh V; Chowdhury K; Groner B;
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正文语种 eng
中图分类细胞生物学;
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1. MicroRNA-dependent regulation of the microenvironment and the epithelial stromal cell interactions in the mouse mammary gland. [J] . Ucar A, Vafaizadeh V, Chowdhury K, Cell cycle . 2011,第4期

机译：小鼠乳腺中微环境和上皮基质细胞相互作用的MicroRNA依赖性调节。
2. Host microenvironment in breast cancer development: Epithelial-cell–stromal-cell interactions and steroid hormone action in normal and cancerous mammary gland [J] . Sandra Z Haslam, Terry L Woodward Breast Cancer Research . 2003,第4期

机译：乳腺癌发展的宿主微环境：正常和癌性乳腺中的上皮细胞-基质细胞相互作用和类固醇激素作用
3. Circadian clock and cell cycle gene expression in mouse mammary epithelial cells and in the developing mouse mammary gland. [J] . Metz RP, Qu X, Laffin B, Developmental dynamics: an official publication of the American Association of Anatomists . 2006,第1期

机译：昼夜节律时钟和细胞周期基因在小鼠乳腺上皮细胞和发育中的小鼠乳腺中的表达。
4. Regulation of autophagy by miR-30a-3p in the mouse mammary epithelial cells [C] . L.Tian, C.M.Wang, L.Zhang, The 6th International Symposium on Dairy Cow Nutrition and Milk Quality（第六届“奶牛营养与牛奶质量”国际研讨会）论文集 . -1

机译：MiR-30a-3p在小鼠乳腺上皮细胞中进行自噬调节
5. Microenvironment growth control of mouse mammary epithelial cells. [D] . Yu, Hongmei. 2006

机译：小鼠乳腺上皮细胞的微环境生长控制。
6. Host microenvironment in breast cancer development: Epithelial-cell–stromal-cell interactions and steroid hormone action in normal and cancerous mammary gland [O] . Sandra Z Haslam, Terry L Woodward 2003

机译：乳腺癌发展中的宿主微环境：正常和癌性乳腺中的上皮细胞-基质细胞相互作用和类固醇激素作用
7. MicroRNA-dependent regulation of the microenvironment and the epithelial stromal cell interactions in the mouse mammary gland [O] . Ucar, A., Vafaizadeh, V., Chowdhury, K., 2011

机译：微小RNa依赖性调节微环境和小鼠乳腺中的上皮基质细胞相互作用

MicroRNA-dependent regulation of the microenvironment and the epithelial stromal cell interactions in the mouse mammary gland.

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