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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Prostate-specific antigen kinetics following external-beam radiotherapy and temporary (Ir-192) or permanent (I-125) brachytherapy for prostate cancer.
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Prostate-specific antigen kinetics following external-beam radiotherapy and temporary (Ir-192) or permanent (I-125) brachytherapy for prostate cancer.

机译：前列腺癌的外部束放疗和临时（Ir-192）或永久（I-125）近距离放射治疗后的前列腺特异性抗原动力学。

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BACKGROUND AND PURPOSE: The aim of the study was the evaluation of PSA kinetics after different radiotherapy methods. MATERIALS AND METHODS: Two-hundred and ninety five patients received external-beam radiotherapy (EBRT; 70.2 Gy; n=135), Ir-192 brachytherapy as a boost to EBRT (HDR-BT; 18 Gy+50.4 Gy; n=66) or I-125 brachytherapy (LDR-BT; 145 Gy; n=94) as monotherapy. "PSA bounce" was defined as a PSA rise of > or = 0.2 ng/ml followed by spontaneous return to prebounce level or lower, biochemical failure as "nadir+2 ng/ml". RESULTS: Patients without biochemical failure reached a lower nadir after brachytherapy (median < or = 0.05 ng/ml after LDR- and HDR-BT without NHT) in comparison to EBRT (0.55 ng/ml without NHT; p<0.01). Not a single patient without NHT and a nadir <0.1 ng/ml failed biochemically (0% vs. 45% with a nadir > or = 0.1 ng/ml; p<0.01). PSA bounces were found predominantly in the LDR-BT group (42% vs. 23%/20% after HDR-BT/EBRT; p<0.01). In a multivariate Cox regression analysis, LDR-BT and HDR-BT were associated with a significantly lower biochemical failure rate in comparison to EBRT. CONCLUSIONS: PSA kinetics differ significantly following different radiotherapy methods. A lower nadir and a higher biochemical control rate suggest a higher radiobiological efficiency of brachytherapy in comparison to EBRT (with a dose of 70.2 Gy).
机译：背景与目的：本研究的目的是评估不同放疗方法后的PSA动力学。材料与方法：295例患者接受了体外放射疗法（EBRT; 70.2 Gy; n = 135）; Ir-192近距离放射疗法增强了EBRT（HDR-BT; 18 Gy + 50.4 Gy; n = 66） ）或I-125近距离放射疗法（LDR-BT; 145 Gy; n = 94）作为单一疗法。 “ PSA反弹”定义为PSA升高>或= 0.2 ng / ml，然后自发恢复到反弹前的水平或更低，生化失败为“最低点+2 ng / ml”。结果：与EBRT相比，未进行生化治疗失败的患者近距离放射治疗后最低点（LDR-和HDR-BT不使用NHT后中位数<或= 0.05 ng / ml）而不是EBRT（0.55 ng / ml不使用NHT; p <0.01）。没有一个没有NHT且最低点<0.1 ng / ml的患者在生化方面失败（0％，而最低点>或= 0.1 ng / ml的患者为45％; p <0.01）。 PSA反弹主要发现于LDR-BT组（HDR-BT / EBRT后为42％，而HDR-BT / EBRT后为23％/ 20％; p <0.01）。在多元Cox回归分析中，与EBRT相比，LDR-BT和HDR-BT与生化失败率显着降低有关。结论：不同放疗方法对PSA动力学的影响显着不同。与EBRT（剂量为70.2 Gy）相比，最低点和较高的生化控制率表明近距离放射疗法的放射生物学效率更高。

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