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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Dose-response relations for stricture in the proximal oesophagus from head and neck radiotherapy.
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Dose-response relations for stricture in the proximal oesophagus from head and neck radiotherapy.

机译：头颈部放疗中近端食管狭窄的剂量反应关系。

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BACKGROUND AND PURPOSE: Determination of the dose-response relations for oesophageal stricture after radiotherapy of the head and neck. MATERIAL AND METHODS: In this study 33 patients who developed oesophageal stricture and 39 patients as controls are included. The patients received radiation therapy for head and neck cancer at Karolinska University Hospital, Stockholm, Sweden. For each patient the 3D dose distribution delivered to the upper 5 cm of the oesophagus was analysed. The analysis was conducted for two periods, 1992-2000 and 2001-2005, due to the different irradiation techniques used. The fitting has been done using the relative seriality model. RESULTS: For the treatment period 1992-2005, the mean doses were 49.8 and 33.4 Gy, respectively, for the cases and the controls. For the period 1992-2000, the mean doses for the cases and the controls were 49.9 and 45.9 Gy and for the period 2001-2005 were 49.8 and 21.4 Gy. For the period 2001-2005 the best estimates of the dose-response parameters are D(50)=61.5 Gy (52.9-84.9 Gy), gamma=1.4 (0.8-2.6) and s=0.1 (0.01-0.3). CONCLUSIONS: Radiation-induced strictures were found to have a dose response relation and volume dependence (low relative seriality) for the treatment period 2001-2005. However, no dose response relation was found for the complete material.
机译：背景与目的：确定头颈部放疗后食管狭窄的剂量反应关系。材料与方法：本研究包括33例发生食管狭窄的患者和39例作为对照的患者。患者在瑞典斯德哥尔摩的卡罗林斯卡大学医院接受了头颈癌的放射治疗。对于每位患者，分析了递送至食管上部5 cm的3D剂量分布。由于使用了不同的辐照技术，因此进行了1992-2000年和2001-2005年这两个时期的分析。拟合已使用相对序列模型完成。结果：在1992-2005年治疗期间，病例和对照的平均剂量分别为49.8和33.4 Gy。在1992-2000年期间，病例和对照组的平均剂量分别为49.9和45.9 Gy，在2001-2005年期间为49.8和21.4 Gy。对于2001年至2005年期间，剂量响应参数的最佳估计值是D（50）= 61.5 Gy（52.9-84.9 Gy），γ= 1.4（0.8-2.6）和s = 0.1（0.01-0.3）。结论：在2001年至2005年的治疗期间，发现辐射引起的狭窄与剂量反应和剂量依赖性（相对序列低）有关。但是，没有发现完整材料的剂量反应关系。

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