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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Long-term quality-of-life after neoadjuvant short-course radiotherapy and long-course radiochemotherapy for locally advanced rectal cancer
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Long-term quality-of-life after neoadjuvant short-course radiotherapy and long-course radiochemotherapy for locally advanced rectal cancer

机译：新辅助短程放疗和长程放化疗治疗局部晚期直肠癌后的长期生活质量

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Purpose To evaluate long-term quality-of-life (QoL) after neoadjuvant short-course radiotherapy (SC-RT) and long-course radiochemotherapy (LC-RCHT) for locally advanced rectal cancer. Methods Between 1999 and 2008, 225 patients were treated with curative intent for locally advanced rectal cancer using neoadjuvant SC-RT (n = 108) or LC-RCHT (n = 117). SC-RT delivered 10 × 2.9 Gy twice daily with immediate surgery. LC-RCHT delivered 28 × 1.8 Gy concomitant with 5-FU based chemotherapy and delayed surgery. A cross-sectional QoL analysis was performed in disease-free patients using the EORTC-QLQ-C30 and EORTC-QLQ-CR29 questionnaires. Results After a median follow-up of 67 months, 133 patients were disease-free of which 120 (90%) returned the QoL questionnaires. Patients in the LC-RCHT cohort had a higher rate of uT4, uN+ and low tumor location. No difference in QoL was observed between SC-RT and LC-RCHT except an improved physical functioning in the LC-RCHT group (p = 0.04). Comparing our total patient cohort with the general German population showed no difference in global health status but decreased QoL in several functional and bowel symptom scores. Conclusions The finding of comparable long-term QoL after SC-RT and LC-RCHT adds to our knowledge of equivalent oncological outcome and may be useful in the decision making process between the two neoadjuvant approaches.
机译：目的评估局部晚期直肠癌的新辅助短程放疗（SC-RT）和长程放化疗（LC-RCHT）后的长期生活质量（QoL）。方法在1999年至2008年间，采用新辅助SC-RT（n = 108）或LC-RCHT（n = 117）对225例局部晚期直肠癌患者进行了根治性治疗。 SC-RT立即手术两次，每天两次提供10×2.9 Gy。 LC-RCHT伴随着基于5-FU的化学疗法和延迟手术而提供了28×1.8 Gy。使用EORTC-QLQ-C30和EORTC-QLQ-CR29问卷对无病患者进行横断面QoL分析。结果在中位随访67个月后，有133例患者无病，其中120例（90％）返回了QoL问卷。 LC-RCHT队列中的患者的uT4，uN +发生率较高且肿瘤位置较低。除了LC-RCHT组的身体机能得到改善外，SC-RT和LC-RCHT之间的QoL没有差异（p = 0.04）。将我们的总患者队列与德国普通人群进行比较，发现总体健康状况没有差异，但是一些功能和肠症状评分的QoL降低了。结论SC-RT和LC-RCHT后可比较的长期QoL的发现增加了我们对等效肿瘤学结局的了解，可能在两种新辅助方法之间的决策过程中有用。

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