...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Stereotactic body radiation therapy in the treatment of multiple primary lung cancers
【24h】

Stereotactic body radiation therapy in the treatment of multiple primary lung cancers

机译：立体定向放射疗法治疗多种原发性肺癌

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and purpose: Patients with multiple primary lung cancers (MPLC) present a therapeutic dilemma, particularly when they are at high risk for surgical resection. We evaluated the role of stereotactic body radiation therapy (SBRT) in the treatment of MPLC. Materials and methods: A prospective thoracic SBRT registry was explored for patients with either synchronous or metachronous MPLC treated with SBRT for one or both of their tumors. Sixty-three patients were identified and clinical data were analyzed. Results: Fifteen patients had synchronous lesions and 48 patients had metachronous lesions. Seventy-six lesions were treated with SBRT. Median follow-up was 24 months for living patients. Median progression-free survival (PFS) and overall survival (OS) for the entire cohort was 15.5 and 20 months, respectively. Patients with metachronous MPLC had a significantly higher 2 year PFS (53.3% vs. 0%, p = 0.0466) compared to patients with synchronous MPLC. Likewise, 2 year OS was also superior for patients with metachronous versus synchronous MPLC (68.1% vs. 27.5%, p = 0.0014). Six tumors (7.9%) recurred within the radiation field. There were no grade ≥3 toxicities. Conclusions: SBRT for patients with MPLC appears to be a safe and effective local treatment alternative to surgery, particularly for medically inoperable patients. Patients with metachronous MPLC have encouraging survival rates, and thus local therapy appears justified. However, patients with synchronous MPLC have poor OS and PFS despite having excellent local control, and thus the utility of local therapy in this population requires further study.
机译：背景与目的：患有多种原发性肺癌（MPLC）的患者存在治疗难题，尤其是在他们有较高的手术切除风险时。我们评估了立体定向放射治疗（SBRT）在MPLC治疗中的作用。材料和方法：对前瞻性胸部SBRT登记册进行了研究，探讨了采用SBRT治疗同步或异时MPLC的一个或两个肿瘤患者。确定了63例患者并分析了临床数据。结果：15例有同步性病变，48例有同步性病变。 SBRT治疗了76个病变。在世患者的中位随访时间为24个月。整个队列的中位无进展生存期（PFS）和总体生存期（OS）分别为15.5和20个月。与同步MPLC患者相比，异时MPLC患者的2年PFS显着更高（53.3％比0％，p = 0.0466）。同样，与同步MPLC相比，同期MPLC患者的2年OS也更好（68.1％vs. 27.5％，p = 0.0014）。在放射野内复发了六个肿瘤（7.9％）。没有毒性≥3级。结论：对于MPLC患者，SBRT似乎是一种安全有效的局部手术替代手术，特别是对于无法手术的患者。异时MPLC患者的存活率令人鼓舞，因此局部治疗似乎是合理的。但是，尽管同步MPLC患者具有出色的局部控制能力，但他们的OS和PFS仍然较差，因此在该人群中使用局部治疗尚需进一步研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号