Multivariable normal tissue complication probability model-based treatment plan optimization for grade 2-4 dysphagia and tube feeding dependence in head and neck radiotherapy

Kierkels Roel G. J.; Wopken Kim; Visser Ruurd; Korevaar Erik W.; van der Schaaf Arjen; Bijl Hendrik P.; Langendijk Johannes A.

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Multivariable normal tissue complication probability model-based treatment plan optimization for grade 2-4 dysphagia and tube feeding dependence in head and neck radiotherapy

机译：基于多变量正常组织并发症概率模型的头颈部放疗2-4级吞咽困难和管饲依赖的治疗计划优化

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摘要

Background and purpose: Radiotherapy of the head and neck is challenged by the relatively large number of organs-at-risk close to the tumor. Biologically-oriented objective functions (OF) could optimally distribute the dose among the organs-at-risk. We aimed to explore OFs based on multivariable normal tissue complication probability (NTCP) models for grade 2-4 dysphagia (DYS) and tube feeding dependence (TFD).

机译：背景与目的：靠近肿瘤的大量处于危险中的器官挑战着头颈部的放射疗法。面向生物学的目标函数（OF）可以在高风险器官之间最佳地分配剂量。我们旨在探索基于多变量正常组织并发症概率（NTCP）模型的2-4级吞咽困难（DYS）和管饲依赖（TFD）的OF。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2016年第3期|共7页
作者
Kierkels Roel G. J.; Wopken Kim; Visser Ruurd; Korevaar Erik W.; van der Schaaf Arjen; Bijl Hendrik P.; Langendijk Johannes A.;
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正文语种 eng
中图分类肿瘤学;
关键词
Head and neck cancer; Multivariable NTCP models; Tube feeding dependence; Swallowing dysfunction; Biological-oriented treatment plan optimization; Multi-criteria optimization;

机译：头颈癌;多变量NTCP模型;管饲依赖;吞咽功能障碍;以生物为导向的治疗计划优化;多标准优化;

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1. Multivariable normal tissue complication probability model-based treatment plan optimization for grade 2-4 dysphagia and tube feeding dependence in head and neck radiotherapy [J] . Kierkels Roel G. J., Wopken Kim, Visser Ruurd, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2016,第3期

机译：基于多变量正常组织并发症概率模型的头颈部放疗2-4级吞咽困难和管饲依赖的治疗计划优化
2. Development of a rnultivariable normal tissue complication probability (NTCP) model for tube feeding dependence after curative radiotherapy/chemo-radiotherapy in head and neck cancer [J] . Wopken Kim, Bij Hendrik P., van der Schaaf Arjen, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2014,第1期

机译：头颈部癌根治性放疗/化学放疗后管饲依赖的多变量正常组织并发症概率（NTCP）模型的建立
3. External validation of a multifactorial normal tissue complication probability model for tube feeding dependence at 6?months after definitive radiotherapy for head and neck cancer [J] . Naoyuki Kanayama, Roel G.J. Kierkels, Arjen van der Schaaf, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2018,第2期

机译：在头部和颈部癌症明确放疗后6月喂养依赖的多因其正常组织并发概率模型的外部验证
4. RadioBio data: A Moddicom Module to Predict Tumor Control Probability and Normal Tissue Complication Probability in Radiotherapy [C] . Nicola Dinapoli, Anna Rita Alitto, Mauro Vallati, International Conference on Health Informatics . 2016

机译：radiobio数据：Moddicom模块，以预测放射治疗中肿瘤控制概率和正常组织并发症概率
5. Incorporating spatial dose metrics in machine learning-based normal tissue complication probability (NTCP) models of severe acute dysphagia resulting from head and neck radiotherapy [O] . Jamie Dean, Kee Wong, Hiram Gay, 2018

机译：在基于机器学习的头颈部放疗导致的严重急性吞咽困难的基于机器学习的正常组织并发症概率（NTCP）模型中纳入空间剂量指标
6. Development of a multivariable normal tissue complication probability (NTCP) model for tube feeding dependence after curative radiotherapy/chemo-radiotherapy in head and neck cancer [O] . Wopken, Kim, Bijl, Hendrik P., van der Schaaf, Arjen, 2014

机译：头颈部癌根治性放射治疗/化学放射治疗后管饲依赖的多变量正常组织并发症概率（NTCP）模型的建立

Multivariable normal tissue complication probability model-based treatment plan optimization for grade 2-4 dysphagia and tube feeding dependence in head and neck radiotherapy

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