Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

Andreassen Christian Nicolaj; Rosenstein Barry S.; Kerns Sarah L.; Ostrer Harry; De Ruysscher Dirk; Cesaretti Jamie A.; Barnett Gillian C.; Dunning Alison M.; Dorling Leila; West Catharine M. L.; Burnet Neil G.; Elliott Rebecca; Coles Charlotte; Hall Emma; Fachal Laura; Vega Ana; Gomez-Caamano Antonio; Talbot Christopher J.; Symonds R. Paul; De Ruyck Kim; Thierens Hubert; Ost Piet; Chang-Claude Jenny; Seibold Petra; Popanda Odilia; Overgaard Marie; Dearnaley David; Sydes Matthew R.; Azria David; Koch Christine Anne; Parliament Matthew; Blackshaw Michael; Sia Michael; Fuentes-Raspall Maria J.; Ramon y Cajal Teresa; Barnadas Agustin; Vesprini Danny; Gutierrez-Enriquez Sara; Molla Meritxell; Diez Orland; Yarnold John R.; Overgaard Jens; Bentzen Soren M.; Alsner Jan

首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

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Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

机译：个别患者数据荟萃分析显示，ATM rs1801516 SNP与5456名乳腺癌和前列腺癌患者放疗后的毒性之间存在显着关联

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Purpose: Several small studies have indicated that the ATM rsl 801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium.

机译：目的：几项小型研究表明，ATM rsl 801516 SNP与放疗后正常组织毒性的风险有关。但是，发现并不一致。为了在功能强大的研究中测试此SNP，国际放射基因组学协会对患者的个人数据进行了荟萃分析。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2016年第3期|共9页
作者
Andreassen Christian Nicolaj; Rosenstein Barry S.; Kerns Sarah L.; Ostrer Harry; De Ruysscher Dirk; Cesaretti Jamie A.; Barnett Gillian C.; Dunning Alison M.; Dorling Leila; West Catharine M. L.; Burnet Neil G.; Elliott Rebecca; Coles Charlotte; Hall Emma; Fachal Laura; Vega Ana; Gomez-Caamano Antonio; Talbot Christopher J.; Symonds R. Paul; De Ruyck Kim; Thierens Hubert; Ost Piet; Chang-Claude Jenny; Seibold Petra; Popanda Odilia; Overgaard Marie; Dearnaley David; Sydes Matthew R.; Azria David; Koch Christine Anne; Parliament Matthew; Blackshaw Michael; Sia Michael; Fuentes-Raspall Maria J.; Ramon y Cajal Teresa; Barnadas Agustin; Vesprini Danny; Gutierrez-Enriquez Sara; Molla Meritxell; Diez Orland; Yarnold John R.; Overgaard Jens; Bentzen Soren M.; Alsner Jan;
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正文语种 eng
中图分类肿瘤学;
关键词
Normal tissue toxicity; Radiosensitivity; Ataxia telangiectasia mutated; p.Asp1853Asn; c.5557G gt; A;

机译：正常组织毒性;放射敏感性;共济失调毛细血管扩张症;p.Asp1853Asn;c.5557G A;

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1. Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients [J] . Andreassen Christian Nicolaj, Rosenstein Barry S., Kerns Sarah L., Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2016,第3期

机译：个别患者数据荟萃分析显示，ATM rs1801516 SNP与5456名乳腺癌和前列腺癌患者放疗后的毒性之间存在显着关联
2. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. [J] . Darby S, McGale P, Correa C, The Lancet . 2011,第9804期

机译：放疗后哺乳期手术后的效果10年复发和15年乳腺癌死亡：17名随机试验中10,801名妇女的个体患者数据的Meta分析。
3. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. [J] . Darby S, McGale P, Correa C, The Lancet . 2011,第9804期

机译：放疗后哺乳期手术后的效果10年复发和15年乳腺癌死亡：17名随机试验中10,801名妇女的个体患者数据的Meta分析。
4. Survival Rate of Radiotherapy Treatments with 3D-CRT and SBRT Techniques in Patients with Prostate Cancer CaP at the Centro Médico Nacional Siglo XXI-IMSS, Hospital de Oncologia [C] . Christian Adame González, José Trinidad Alvarez Romero, Mario Moranchel y Rodriguez, Mexican Symposium on Medical Physics . 2019

机译：在CentroMédicoNacionalsigloXXI-IMSS，Hospital De Mocologia患者中患有3D-CRT和SBRT技术的放射治疗治疗患者的放疗率和SBRT技术
5. Analysis of Single Nucleotide Polymorphisms (SNPs) and Dose-volume Parameters on Predicting for Rectal Toxicity, Erectile Dysfunction, and Urinary Morbidity Following Treatment for Prostate Cancer Using Radiotherapy. [D] . Taneja, Sameer. 2014

机译：分析单核苷酸多态性（SNP）和剂量参数对使用放射疗法治疗前列腺癌后的直肠毒性，勃起功能障碍和尿毒症的预测。
6. Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients [O] . Christian Nicolaj Andreassen, Barry S. Rosenstein, Sarah L. Kerns, -1

机译：个别患者数据荟萃分析显示ATM rs1801516 SNP与5456乳腺癌和前列腺癌患者放疗后的毒性之间存在显着关联
7. Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients [O] . Andreassen, Christian Nicolaj, Rosenstein, Barry S., Kerns, Sarah L., 2016

机译：个别患者数据荟萃分析显示，ATM rs1801516 SNP与5456乳腺癌和前列腺癌患者放疗后的毒性之间存在显着关联
8. Genome Wide Association Study to Identify SNPs and CNPs Associated with Development of Radiation Injury in Prostate Cancer Patients Treated with Radiotherapy. [R] . Rosenstein, B. S., Ostrer, H. 2012

机译：基因组广泛关联研究，以确定与放射治疗前列腺癌患者的辐射损伤发展相关的sNps和CNps。

Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

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