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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Poorer outcome in Polynesian patients with prostate cancer treated with definitive conformational radiation therapy.
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Poorer outcome in Polynesian patients with prostate cancer treated with definitive conformational radiation therapy.

机译：用确定性构象放射疗法治疗的波利尼西亚前列腺癌患者的预后较差。

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摘要

PURPOSE: To compare freedom from biochemical failure (FFBF) of French Polynesian (FP) and Native European (NE) prostate cancer patients after definitive conformal radiotherapy (RT). PATIENTS AND METHODS: Data were reviewed from medical records of 152 consecutive patients (46 FP and 106 NE) with clinically localised prostate cancer treated with definitive RT. Neoadjuvant androgen deprivation therapy (ADT) was used in 22% of cases. Definition for biochemical failure was a rise by 2 ng/mL or more above the nadir prostate-specific antigen (PSA) level. The median follow-up was 34 months. RESULTS: In comparison to NE patients, FP patients were younger (p=0.002) with a higher low-risk proportion (p=0.06). Probability of 5-year FFBF was 77% in the NE cohort and 58.0% in the FP cohort (p=0.017). Univariate analysis showed that FP ethnicity was associated with worse prognosis in high-risk tumours (p=0.004). Cox multivariate analysis showed that factors associated with FFBF were risk category (p<0.017), and FP origin (p=0.03), independently of ADT and radiation dose. CONCLUSION: FP ethnicity was an independent prognostic factor for biochemical relapse after definitive conformal RT for prostate cancer.
机译：目的：比较定形适形放疗（RT）后法属波利尼西亚人（FP）和欧洲原住民（NE）前列腺癌患者免于生化衰竭（FFBF）的可能性。病人和方法：数据来自152例连续行定性放疗的临床局限性前列腺癌患者（46 FP和106 NE）的病历。 22％的病例使用了新辅助雄激素剥夺疗法（ADT）。生化衰竭的定义是比最低谷前列腺特异性抗原（PSA）水平高2 ng / mL或更多。中位随访时间为34个月。结果：与NE患者相比，FP患者年轻（p = 0.002），低危比例更高（p = 0.06）。 5年FFBF的概率在NE队列中为77％，在FP队列中为58.0％（p = 0.017）。单因素分析表明，FP族裔与高危肿瘤的预后较差有关（p = 0.004）。 Cox多变量分析显示，与FFBF相关的因素是危险类别（p <0.017）和FP起源（p = 0.03），与ADT和辐射剂量无关。结论：FP种族是确定性适形RT后前列腺癌生化复发的独立预后因素。

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