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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Comparison of radiography- and computed tomography-based treatment planning in cervix cancer in brachytherapy with specific attention to some quality assurance aspects.
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Comparison of radiography- and computed tomography-based treatment planning in cervix cancer in brachytherapy with specific attention to some quality assurance aspects.

机译：在近距离放射治疗中子宫颈癌的放射线和计算机断层扫描的治疗计划的比较，尤其要注意一些质量保证方面。

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INTRODUCTION: A modern approach in treatment planning for cervix carcinoma is based on a series of computed tomography (CT) sections and 3D dose computation. When these techniques were not yet available, dose evaluation was based on orthogonal radiographs. The CT based planning provides information on target and organ volumes and dose-volume histograms. The radiography based planning provides only dimensions and doses at selected points. The aim of the presented study is to correlate the information obtained with the two approaches for high dose-rate (HDR) brachytherapy of cervix carcinoma. METHODS: For the study 28 patients with 35 applications receiving HDR treatment with Ir-192 were investigated. The planning system PLATO (Nucletron) was used. The different aspects of available data, results and inaccuracies regarding quality assurance were looked at. RESULTS: From the CT based planning, the volume, location and dose-volume histograms were calculated for the CTV, rectum and bladder. From the radiography-based planning, the dose to point A (prescription), point B, rectum and bladder ICRU reference points [14], points related to the bony structures could be evaluated as well as volumes receiving different dose levels. These two sets of information were compared and following mean values derived. For a dose prescription of 7 Gy at point A, as an average, 83% (44 cm(3)) of the clinical target volume (CTV) receives at least 7 Gy. The mean dose at the rectum ICRU reference point is 4.3 Gy, and 12% (9 cm(3)) of the rectum is encompassed by the 4.3 Gy isodose. The mean dose at the bladder ICRU reference point is 5.8 Gy, and 8% (16 cm(3)) of the bladder is encompassed by the 5.8 Gy isodose. The maximum dose to the rectum is 1.5 times higher than the dose at the ICRU reference point, and for the bladder 1.4 times higher. Uncertainties caused by the reconstruction of the applicator and merging of isodoses could be evaluated. DISCUSSION: The subdivision of different approaches and the transfer from point doses to volumes in treatment planning is possible and practical for the treatment of cervix carcinoma in brachytherapy.
机译：简介：宫颈癌治疗规划的现代方法是基于一系列计算机断层扫描（CT）切片和3D剂量计算。当这些技术尚不可用时，剂量评估是基于正交射线照相。基于CT的计划可提供有关靶标和器官体积以及剂量-体积直方图的信息。基于射线照相的计划仅在选定点提供尺寸和剂量。本研究的目的是将获得的信息与宫颈癌高剂量率（HDR）近距离放射治疗的两种方法相关联。方法：本研究调查了28例35例接受Ir-192 HDR治疗的患者。使用了计划系统PLATO（Nucletron）。研究了可用数据的不同方面，结果以及有关质量保证的不准确性。结果：根据基于CT的计划，计算了CTV，直肠和膀胱的体积，位置和剂量体积直方图。从基于放射照相的计划中，可以评估A点（处方），B点，直肠和膀胱ICRU参考点[14]的剂量，以及与骨结构有关的点以及接受不同剂量水平的剂量。比较这两组信息并得出以下平均值。对于A点7 Gy的剂量处方，平均83％（44 cm（3））的临床目标体积（CTV）收到至少7 Gy。直肠ICRU参考点的平均剂量为4.3 Gy，而4.3 Gy等剂量剂量占直肠的12％（9 cm（3））。膀胱ICRU参考点的平均剂量为5.8 Gy，而5.8 Gy的等剂量剂量为膀胱的8％（16 cm（3））。直肠的最大剂量比ICRU参考点的剂量高1.5倍，膀胱的最大剂量高1.4倍。可以评估由于涂药器的改造和等位基因的合并所引起的不确定性。讨论：在治疗计划中，不同方法的细分以及从点剂量到量的转移对于在近距离放射治疗子宫颈癌中可能是可行的。

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