...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >Radiation sensitivity of GL261 murine glioma model and enhanced radiation response by flavopiridol.
【24h】

Radiation sensitivity of GL261 murine glioma model and enhanced radiation response by flavopiridol.

机译：GL261鼠神经胶质瘤模型的辐射敏感性和黄酮哌啶醇增强的辐射反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Response of a solid tumor to radiation treatment depends, in part, on the intrinsic radiosensitivity of tumor cells, the proliferation rate of tumor cells between radiation treatments and the hypoxic state of the tumor cells. A successful radiosensitizing agent would target S-phase cells and hypoxia. Recently, we demonstrated the anti-tumor effects of flavopiridol in the GL261 murine glioma model might involve 1) recruitment of tumor cells to S-phase (Newcomb et al Cell Cycle 2004; 3:230-234) and 2) an anti-angiogenic effect on the tumor vasculature by downregulation of hypoxia-inducible factor -1alpha (HIF-1alpha) (Newcomb et al Neuro-Oncology 2005; 7:225-235). Given that flavopiridol has demonstrated radiosensitizing activity in several murine tumor models, we tested whether it would enhance the response of GL261 tumors to radiation. In the present study, we evaluated the intrinsic radiation sensitivity of the GL261 glioma model using the tumor control/cure dose of radiation assay (TCD(50)). We foundthat a single dose of 65 Gy (CI 57.1-73.1) was required to cure 50% of the tumors locally. Using the tumor growth delay assay, fractionated radiation (5 fractions of 5 Gy over 10 days) combined with flavopiridol (5 mg/kg) given three times weekly for 3 cycles produced a significant growth delay. Our results indicate that the GL261 murine glioma model mimics the radioresistance encountered in human gliomas, and thus should prove useful in identifying promising new investigational radiosensitizers for use in the treatment of glioma patients.
机译：实体瘤对放射治疗的反应部分取决于肿瘤细胞的固有放射敏感性，放射治疗之间肿瘤细胞的增殖速率和肿瘤细胞的低氧状态。成功的放射增敏剂将靶向S期细胞和缺氧。最近，我们证明了黄酮哌啶醇在GL261鼠神经胶质瘤模型中的抗肿瘤作用可能涉及1）将肿瘤细胞募集至S期（Newcomb等，Cell Cycle 2004; 3：230-234）和2）抗血管生成缺氧诱导因子-1α（HIF-1alpha）的下调对肿瘤血管的影响（Newcomb等Neuro-Oncology 2005; 7：225-235）。鉴于黄酮哌啶醇已在几种鼠类肿瘤模型中显示出放射增敏活性，我们测试了其是否会增强GL261肿瘤对放射的反应。在本研究中，我们使用肿瘤控制/治愈剂量的放射测定法（TCD（50））评估了GL261神经胶质瘤模型的固有放射敏感性。我们发现需要单剂量65 Gy（CI 57.1-73.1）才能局部治愈50％的肿瘤。使用肿瘤生长延迟测定法，每周3次，连续3个周期的分级放疗（在10天之内5个5 Gy分数）与黄酮哌啶醇（5 mg / kg）组合产生了明显的生长延迟。我们的结果表明，GL261鼠神经胶质瘤模型可模拟人类神经胶质瘤中遇到的放射抗性，因此应证明对确定用于治疗神经胶质瘤患者的新的有研究意义的新型放射增敏剂很有用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号