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首页> 外文期刊>Cell cycle >The HIRAN domain and recruitment of chromatin remodeling and repair activities to damaged DNA.
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The HIRAN domain and recruitment of chromatin remodeling and repair activities to damaged DNA.

机译：HIRAN结构域和染色质重塑的募集以及对受损DNA的修复活性。

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摘要

Aided by sensitive sequence profile searches we identify a novel conserved domain in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p (hence HIP116, Rad5p N-terminal domain: HIRAN domain). We show that the HIRAN domain is found as a standalone protein in several bacteria and prophages, or fused to other catalytic domains, such as a nuclease of the restriction endonuclease fold and TDP1-like DNA phosphoesterases, in the eukaryotes. Based on a network of contextual connections in the form of domain architectures, conserved gene neighborhoods and functional interactions we predict that the HIRAN domain is likely to function as a DNA-binding domain that probably recognizes features associated with damaged DNA or stalled replication forks. It might thus act as a sensor to initiate a damaged DNA checkpoint and engage different DNA repair and chromatin remodeling or modifying activities to these sites. In evolutionary terms, the fusion of the HIRAN domain, and the functionally analogous RAD18 Zn-finger and the PARP-type Zn-finger to SWI2/SNF2 ATPases appears to have been a notable factor for recruiting these ATPases for chromatin modification and remodeling in the context of DNA repair.
机译：通过敏感的序列概况搜索，我们在以HIP116和Rad5p为代表的SWI2 / SNF2蛋白的N端区域中识别了一个新的保守域（因此，HIP116，Rad5p N端域：HIRAN域）。我们表明，HIRAN结构域在几种细菌和原噬菌体中作为独立蛋白被发现，或与其他催化结构域融合，例如在真核生物中限制性内切核酸酶折叠的核酸酶和TDP1样DNA磷酸酯酶。基于域结构，保守的基因邻域和功能相互作用形式的上下文连接网络，我们预测HIRAN域可能充当DNA结合域，该域可能识别与受损DNA或停滞的复制叉相关的特征。因此，它可以充当传感器来启动受损的DNA检查点，并使这些位置参与不同的DNA修复和染色质重塑或修饰活动。从进化的角度来看，HIRAN结构域以及功能类似的RAD18锌指和PARP型锌指与SWI2 / SNF2 ATPase的融合似乎是招募这些ATPase进行染色质修饰和重塑的重要因素。 DNA修复的背景。

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