Analysis of BRAF mutation in primary and metastatic melanoma.

Libra M; Malaponte G; Navolanic PM; Gangemi P; Bevelacqua V; Proietti L; Bruni B; Stivala F; Mazzarino MC; Travali S; McCubrey JA

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Analysis of BRAF mutation in primary and metastatic melanoma.

机译：原发性和转移性黑色素瘤的BRAF突变分析。

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Mutation of BRAF has been proposed to contribute to melanoma development. However, it remains unclear whether or not BRAF mutation is associated with any particular stage of melanoma progression. Tumor biopsy specimens from patients with melanoma were analyzed to determine whether the frequency of BRAF mutation in metastatic melanoma differed from primary melanoma. BRAF mutation was present in 15 of 23 (61%) patients with primary melanoma and in 7 of 12 (58%) patients with metastatic melanoma. These results suggest that BRAF mutation in melanoma is most likely to occur prior to the development of metastatic disease.

机译：已经提出BRAF的突变有助于黑素瘤的发展。然而，目前尚不清楚BRAF突变是否与黑色素瘤进展的任何特定阶段有关。分析来自黑素瘤患者的肿瘤活检标本，以确定转移性黑素瘤中BRAF突变的频率是否与原发性黑素瘤不同。在23例原发性黑色素瘤患者中有15例（61％）和12例转移性黑色素瘤患者中有7例（58％）存在BRAF突变。这些结果表明，黑色素瘤中的BRAF突变最有可能在转移性疾病发展之前发生。

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《Cell cycle》 |2005年第10期|共3页
作者
Libra M; Malaponte G; Navolanic PM; Gangemi P; Bevelacqua V; Proietti L; Bruni B; Stivala F; Mazzarino MC; Travali S; McCubrey JA;
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正文语种 eng
中图分类细胞生物学;
关键词
Melanoma; Mutation; Proto-Oncogene Proteins B-raf; 黑色素瘤; 突变;

机译：Melanoma;Mutation;Proto-Oncogene Proteins B-raf;黑色素瘤;突变;

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1. Analysis of BRAF mutation in primary and metastatic melanoma. [J] . Libra M, Malaponte G, Navolanic PM, Cell cycle . 2005,第10期

机译：原发性和转移性黑色素瘤的BRAF突变分析。
2. Application of immunocytochemistry and BRAF mutational analysis to direct smears of metastatic melanoma. [J] . Kim Hookim, Michael H Roh, Joseph Willman, Cancer: A Journal of the American Cancer Society . 2012,第1期

机译：免疫细胞化学和BRAF突变分析在转移性黑色瘤的直接涂片中的应用。
3. Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma. [J] . Conway C, Beswick S, Elliott F, Genes, Chromosomes and Cancer . 2010,第5期

机译：与BRAF / NRAS突变有关的染色体臂9p缺失和对原发性黑色素瘤的预后意义。
4. Isolation of Circulating Tumor Cells from Patients with Metastatic Colorectal Cancer Using Label-Free Microfluidic Technology for Enumeration and Detection of KRAS, BRAF, PIK3CA Mutation [C] . Haiyan Emily Liu, Evelyn Kidess-Sigal, Melanie Triboulet, International Molecular Medicine Tri-Conference. . 2016

机译：使用无标记微流体技术分离转移性结肠直肠癌患者的循环肿瘤细胞进行募准和检测KRA，BRAF，PIK3CA突变
5. NRAS and BRAF mutations in primary cutaneous melanoma: A comparison of mutation rates between radial and vertical growth phases in individual tumors. [D] . Greene, Victoria R. 2007

机译：原发性皮肤黑素瘤中的NRAS和BRAF突变：单个肿瘤在径向和垂直生长期之间的突变率比较。
6. Allele frequencies of BRAFV600 mutations in primary melanomas and matched metastases and their relevance for BRAF inhibitor therapy in metastatic melanoma [O] . Imke Satzger, Lena Marks, Martin Kerick, 2015

机译：原发性黑色素瘤和匹配转移瘤中BRAFV600突变的等位基因频率及其与BRAF抑制剂治疗转移性黑色素瘤的相关性
7. Intra- and inter-tumor heterogeneity of BRAF(V600E))mutations in primary and metastatic melanoma. [O] . Molly Yancovitz, Adam Litterman, Joanne Yoon, 2012

机译：原发性和转移性黑素瘤中BRaF（V600E）突变的肿瘤内和肿瘤间异质性。

Analysis of BRAF mutation in primary and metastatic melanoma.

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