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首页> 外文期刊>Cell cycle >Hematopoietic stem cells, leukemic stem cells and chronic myelogenous leukemia.
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Hematopoietic stem cells, leukemic stem cells and chronic myelogenous leukemia.

机译：造血干细胞，白血病干细胞和慢性粒细胞性白血病。

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摘要

Blood-related cancers, or leukemias, have been shown to arise from a rare subset of cells that escape normal regulation and drive the formation and growth of the tumor. The finding that these so-called cancer stem cells, or leukemic stem cells (LSC), can be purified away from the other cells in the tumor allows their precise analysis to identify candidate molecules and regulatory pathways that play a role in progression, maintenance, and spreading of leukemias. The analyses of the other, numerically dominant, cells in the tumor, while also interesting, do not directly interrogate these key properties of malignancies. Mouse models of human myeloproliferative disorder and acute myelogenous leukemia have highlighted the remarkable conservation of disease mechanisms between both species. They can now be used to identify the LSC for each type of human leukemia and understand how they escape normal regulation and become malignant. Given the clinical importance of LSC identification, the insights gained through these approaches will quickly translate into clinical applications and lead to improved treatments for human leukemias.
机译：血液相关的癌症或白血病已被证明是由罕见的逃避正常调节并驱动肿瘤形成和生长的细胞亚群引起的。这些所谓的癌症干细胞或白血病干细胞（LSC）可以从肿瘤中的其他细胞中纯化出来的发现，可以对其进行精确分析，以鉴定在进展，维持，和白血病的蔓延。对肿瘤中其他在数量上占优势的细胞的分析虽然也很有趣，但并不能直接询问这些恶性肿瘤的这些关键特性。人类骨髓增生性疾病和急性骨髓性白血病的小鼠模型突显了这两种物种之间疾病机制的显着保守性。现在，它们可以用于识别每种类型的人类白血病的LSC，并了解它们如何逃避正常调节并变得恶性。鉴于LSC鉴定的临床重要性，通过这些方法获得的见识将迅速转化为临床应用，并导致改善的人类白血病治疗方法。

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