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Micro-managing the pancreatic β cell

机译:微观管理胰腺β细胞

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摘要

In his writings on the milieu interieur, Claude Bernard first hypothesized on the presence of feedback mechanisms within the cell to maintain its steady-state physiology. Walter Bradford Cannon would subsequently build on this concept and coin the term homeostasis. To date, numerous counter-regulatory mechanisms have been characterized in the cell, illustrating the dynamic nature of the intracellular environment. Among the more recently discovered is the microRNA (miRNA) pathway, and as of this writing, 2578 mature human miRNAs have been annotated in the miR-Base database V20, which now catalogs 206 different plant and animal species.
机译:克劳德·伯纳德(Claude Bernard)在关于环境问题的著作中,首先假设了细胞内是否存在维持其稳态生理的反馈机制。沃尔特·布拉德福德·坎农(Walter Bradford Cannon)随后将在这个概念上立足,并创造了术语稳态。迄今为止,细胞中已经表征了许多反调节机制,说明了细胞内环境的动态性质。在最近发现的是microRNA(miRNA)途径中,截至撰写本文时,在miR-Base数据库V20中已注释了2578个成熟的人类miRNA,该数据库现已对206种不同的动植物物种进行了分类。

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