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首页> 外文期刊>Cell cycle >From cell cycle to differentiation: an expanding role for cdk6.
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From cell cycle to differentiation: an expanding role for cdk6.

机译：从细胞周期到分化：cdk6的扩展作用。

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Over ten years ago, cdk6 was identified as a new member in a family of vertebrate cdc-2 related kinases. This novel kinase was found to partner with the D-type cyclins and to possess pRb kinase activity in vitro. Recently, several independent studies in multiple cell types have indicated a novel role for cdk6 in differentiation. Since exit from the cell cycle is a necessary step in the process of differentiation, it may not seem surprising that downregulation of a mitogenic factor may be required for this process. It is, however, surprising that this association has not been previously uncovered and that it is apparently not shared with cdk4, long understood to be a functional homolog of cdk6. As this story unfolds it will be important to discover if the role of cdk6 in differentiation is pRb-dependent or pRb-independent, since pRb has long been established as a key factor in initiating and maintaining cell cycle exit during differentiation.
机译：十多年前，cdk6被鉴定为脊椎动物cdc-2相关激酶家族的新成员。发现这种新型激酶与D型细胞周期蛋白结合并在体外具有pRb激酶活性。最近，对多种细胞类型的几项独立研究表明，cdk6在分化中具有新作用。由于从细胞周期中退出是分化过程中的必要步骤，因此在此过程中可能需要有丝分裂因子的下调似乎不足为奇。然而，令人惊奇的是，这种联系以前尚未被发现，并且显然与长期以来被认为是cdk6的功能同源物的cdk4没有共享。随着这个故事的展开，重要的是要发现cdk6在分化中的作用是pRb依赖性还是pRb依赖性，因为pRb长期以来一直被认为是启动和维持分化过程中细胞周期退出的关键因素。

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