Inhibitor of NF kappa B alpha is a host sensor of coxsackievirus infection.

Saura M; Lizarbe TR; Rama-Pacheco C; Lowenstein CJ; Zaragoza C

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Inhibitor of NF kappa B alpha is a host sensor of coxsackievirus infection.

机译：NF kappa B alpha的抑制剂是柯萨奇病毒感染的宿主传感器。

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Apoptosis is a host response to viral infection: programmed cell death can limit viral replication. Therefore, the knowledge of pathways by which cells detect viral infection and activate apoptosis may be of considerable interest when developing strategies against viral pathogens. We have shown that cells activate apoptosis in response to Coxsackievirus B3 (CVB3) infection. In an effort to discover how cells detect viral infections, we found that the viral protease 3C(pro) cleaves IkappaBalpha. Truncated IkappaBalpha forms a stable complex with NFkappaB, translocates to the nucleus and inhibits NFkappaB transactivation, increasing apoptosis and decreasing viral replication. In contrast, cells in which IkappaBalpha expression is reduced are more susceptible to viral infection, showing less apoptosis and more viral replication. IkBalpha thus acts as a sensor of viral infection. Cleavage of host proteins by pathogen proteases is a novel mechanism by which the host recognizes and responds to viral infection.

机译：凋亡是宿主对病毒感染的反应：程序性细胞死亡可以限制病毒复制。因此，当开发针对病毒病原体的策略时，关于细胞检测病毒感染并激活细胞凋亡的途径的知识可能是相当有意义的。我们已经表明，细胞可以响应柯萨奇病毒B3（CVB3）感染激活细胞凋亡。为了发现细胞如何检测病毒感染，我们发现病毒蛋白酶3C（pro）裂解IkappaBalpha。截短的IkappaBalpha与NFkappaB形成稳定的复合物，易位至细胞核并抑制NFkappaB的反式激活，增加细胞凋亡并减少病毒复制。相反，IkappaBalpha表达降低的细胞更容易受到病毒感染，显示出更少的凋亡和更多的病毒复制。因此，IkBalpha可作为病毒感染的传感器。病原体蛋白酶裂解宿主蛋白是宿主识别并响应病毒感染的新机制。

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《Cell cycle》 |2007年第5期|共4页
作者
Saura M; Lizarbe TR; Rama-Pacheco C; Lowenstein CJ; Zaragoza C;
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正文语种 eng
中图分类细胞生物学;
关键词
Coxsackievirus Infections; I-kappa B Proteins; 柯萨奇病毒感染;

机译：Coxsackievirus Infections;I-kappa B Proteins;柯萨奇病毒感染;

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1. Inhibitor of NF kappa B alpha is a host sensor of coxsackievirus infection. [J] . Saura M, Lizarbe TR, Rama-Pacheco C, Cell cycle . 2007,第5期

机译：NF kappa B alpha的抑制剂是柯萨奇病毒感染的宿主传感器。
2. A mechanistic insight into a proteasome-independent constitutive inhibitor kappa B alpha (I kappa B alpha) degradation and nuclear factor kappa B (NF-kappa B) activation pathway in WEHI-231 B-cells [J] . Shumway SD, Miyamoto S The Biochemical Journal . 2004,第0期

机译：深入了解WEHI-231 B细胞中不依赖蛋白酶体的组成性抑制剂kappa B alpha（I kappa B alpha）降解和核因子kappa B（NF-kappa B）激活途径的机制
3. A mechanistic insight into a proteasome-independent constitutive inhibitor kappa B alpha (I kappa B alpha) degradation and nuclear factor kappa B (NF-kappa B) activation pathway in WEHI-231 B-cells [J] . Shumway SD, Miyamoto S The Biochemical Journal . 2004,第Pta1期

机译：深入了解WEHI-231 B细胞中不依赖蛋白酶体的组成性抑制剂kappa B alpha（I kappa B alpha）降解和核因子kappa B（NF-kappa B）激活途径的机制
4. The role of NF-#kappa#B in 1->3-#beta#-glucan (zymosan) induced TNF-#alpha# production [C] . S. Young, J. Ye, D. G. Frazer Beltwide Cotton Conferences . 2000

机译：nf-＃kappa＃b在1-> 3-＃beta＃-glucan（Zymosan）引起的TNF-＃alpha＃生产中的作用
5. NMR studies of the transcriptional inhibitor I kappa B alpha and its interaction with the transcription factor NF kappa B. [D] . Cervantes, Carla F. 2010

机译：转录抑制剂IκB alpha及其与转录因子NFκB相互作用的NMR研究。
6. Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B. [O] . Y C Lin, K Brown, U Siebenlist 1995

机译：NF-κB的活化需要抑制剂IκB-α的蛋白水解：仅信号诱导的IκB-α的磷酸化不会释放活性NF-κB。
7. Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B. [O] . Lin, Y C, Brown, K, Siebenlist, U 1995

机译：NF-κB的活化需要抑制剂IκB-α的蛋白水解：仅信号诱导的IκB-α的磷酸化不会释放活性NF-κB。
8. Hantaan Virus Nucleocapsid Protein Binds to Importin alpha Proteins and Inhibits Tumor Necrosis Factor Alpha-Induced Activation of Nuclear Factor Kappa B [R] . Taylor, S. L., Frias-Staheli, N., Garcia-Sastre, A., 2008

机译：汉坦病毒核衣壳蛋白与进口蛋白α蛋白结合并抑制肿瘤坏死因子α诱导的核因子κB活化

Inhibitor of NF kappa B alpha is a host sensor of coxsackievirus infection.

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