...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >Butyrate and Wnt signaling: a possible solution to the puzzle of dietary fiber and colon cancer risk?
【24h】

Butyrate and Wnt signaling: a possible solution to the puzzle of dietary fiber and colon cancer risk?

机译：丁酸和Wnt信号：解决膳食纤维和结肠癌风险的难题的可能解决方案？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Studies on the protective role of dietary fiber and its breakdown product butyrate against colorectal cancer (CRC) have yielded inconsistent findings. We have reported that butyrate treatment of CRC cells in vitro modulates canonical Wnt signaling, a pathway which is constitutively activated in the majority of CRCs. Analyses of ten human CRC cell lines exposed to butyrate have established that the levels of apoptosis in these cells are dependent upon the fold induction of canonical Wnt transcriptional activity. It is likely that the observed variability in the levels of induced Wnt activity and apoptosis in CRC cells in vitro reflects the existence of different CRC subtypes in vivo. The existence of CRC subtypes, individual- and population-specific variation in butyrate producing colonic microflora, and the time at which the colorectal lesions (early vs. late stage) are exposed to fiber/butyrate are all factors that may influence the protective role of fiber against CRC. We discuss the evidence by which these factors influence the effects of fiber on colonic tumorigenesis and outline experimental approaches for testing these hypotheses.
机译：关于膳食纤维及其分解产物丁酸盐对结直肠癌（CRC）的保护作用的研究结果不一致。我们已经报道了在体外对CRC细胞的丁酸酯治疗调节经典的Wnt信号传导，该途径在大多数CRC中被组成性激活。对十种暴露于丁酸的人CRC细胞系的分析已确定，这些细胞中的凋亡水平取决于经典Wnt转录活性的诱导倍数。体外观察到的在CRC细胞中诱导的Wnt活性和细胞凋亡水平的变化可能反映了体内不同CRC亚型的存在。 CRC亚型的存在，产生丁酸的结肠菌群的个体和群体特异性变异以及结直肠病变（早期与晚期）暴露于纤维/丁酸的时间都是可能影响CRC保护作用的因素。纤维抗CRC。我们讨论了这些因素影响纤维对结肠肿瘤发生的影响的证据，并概述了检验这些假设的实验方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号