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Prion and TNFalpha: TAC(E)it agreement between the prion protein and cell signaling.

机译：Prion和TNFalpha：TAC（E）pr病毒蛋白与细胞信号传导之间的一致。

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Prion diseases are rare and fatal neurodegenerative disorders that occur when the cellular prion protein (PrPC) is converted into a conformationally modified isoform that originates the novel infectious agent, called prion. Although much information is now available on the different routes of prion infection, both the mechanisms underlying prion neurotoxicity and the physiologic role of PrPC remain unclear. By use of a novel paradigm, we have shown in a recent paper that--following a myotoxin-induced degenerative challenge--PrPC is implicated in the morphogenesis of the skeletal muscle of adult mice. PrPC accomplished this task by modulating signaling pathways central to the myogenic process, in particular the p38 kinase pathway. The possibility that PrPC acts in cell signaling has already been suggested after in vitro studies. Using our in vivo approach, we have instead provided proof of the physiologic relevance of PrPC commitment in signaling events, and that PrPC likely performed the task by controlling the activity of the enzyme (TACE) secreting the signaling TNFalpha molecule. After a brief summary of our data, here we will discuss the suggestion, arising from our and other recent findings, implying that regulation of TACE, and of other members of the protease family TACE belongs to, may be exploited by PrPC in different cell contexts. Notably, this advancement of knowledge on PrPC physiology could also shed light on the defense mechanisms against the onset of a more common neurodegenerative disorder than prion disease, such as Alzheimer disease.
机译：the病毒是罕见的致命性神经退行性疾病，当细胞病毒蛋白（PrPC）转化为构象修饰的同工型时，就会发生这种疾病，这种异型起源于称为novel病毒的新型传染原。尽管现在有许多关于病毒感染的不同途径的信息，但是病毒神经毒性的基础机制和PrPC的生理作用仍然不清楚。通过使用一种新颖的范例，我们在最近的一篇论文中表明，在肌毒素诱导的退行性攻击之后，PrPC与成年小鼠骨骼肌的形态发生有关。 PrPC通过调节成肌过程中枢的信号通路，特别是p38激酶通路来完成此任务。在体外研究之后，已经提出了PrPC在细胞信号传导中起作用的可能性。使用我们的体内方法，我们提供了PrPC参与信号活动中生理相关性的证据，并且PrPC可能通过控制分泌信号TNFalpha分子的酶（TACE）的活性来完成了这项任务。在简要概述我们的数据之后，我们将在此讨论来自我们和其他近期发现的建议，这暗示着PrACE可能在不同的细胞环境中利用了TACE和TACE蛋白酶家族其他成员的调控作用。 。值得注意的是，对PrPC生理学知识的这种进步也可以阐明防御机制，以对抗比病毒病（如阿尔茨海默氏病）更常见的神经退行性疾病。

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