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首页> 外文期刊>Cell cycle >Loss of either hypoxia inducible factor 1 or 2 promotes lung cancer cell colonization.
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Loss of either hypoxia inducible factor 1 or 2 promotes lung cancer cell colonization.

机译：缺氧诱导因子1或2的缺失会促进肺癌细胞的定殖。

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Lung cancer is the most common cause of cancer-related death in the United States. In solid tumors including lung cancer, tumor cells proliferate at a rate that exceeds the oxygen supply, resulting in regions of low oxygen tension (hypoxia). Tumor cells adapt to hypoxia by inducing genes involved in angiogenesis or glucose metabolism via the transcription factor hypoxia-inducible factor (HIF). HIF consists of two subunits, HIF-alpha and HIF-beta. Adaptation to hypoxia increases tumor cell invasiveness and metastatic potential, which are the main causes of cancer death. Although HIF is generally considered to promote cancer progression and many efforts have been made to screen for HIF-1 inhibitors as attractive therapeutic agents for cancer, a recent report suggests that deletion of HIF-2a promotes lung cancer development. Thus, the role of HIF in lung cancer is complex and may depend on the stage of cancer development.
机译：在美国，肺癌是与癌症相关的死亡的最常见原因。在包括肺癌在内的实体瘤中，肿瘤细胞的增殖速率超过了供氧量，导致低氧张力区域（缺氧）。肿瘤细胞通过转录因子低氧诱导因子（HIF）诱导参与血管生成或葡萄糖代谢的基因来适应缺氧。 HIF由两个亚基HIF-alpha和HIF-beta组成。适应缺氧会增加肿瘤细胞的浸润性和转移潜力，这是癌症死亡的主要原因。尽管通常认为HIF可以促进癌症进展，并且已经进行了许多努力来筛选HIF-1抑制剂作为有吸引力的癌症治疗剂，但最近的报道表明，HIF-2a的缺失会促进肺癌的发展。因此，HIF在肺癌中的作用很复杂，可能取决于癌症发展的阶段。

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