The actin-binding and bundling protein, EPLIN, is required for cytokinesis.

Chircop M; Oakes V; Graham ME; Ma MP; Smith CM; Robinson PJ; Khanna KK

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The actin-binding and bundling protein, EPLIN, is required for cytokinesis.

机译：肌动蛋白结合和捆绑蛋白EPLIN是胞质分裂所必需的。

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Cytokinesis involves two phases: (1) membrane ingression followed by (2) membrane abscission. The ingression phase generates a cleavage furrow and this requires co-operative function of the actin-myosin II contractile ring and septin filaments. We demonstrate that the actin-binding protein, EPLIN, locates to the cleavage furrow during cytokinesis and this is possibly via association with the contractile ring components, myosin II and the septin, Sept2. Depletion of EPLIN results in formation of multinucleated cells and this is associated with inefficient accumulation of active myosin II (MRLC(S19)) and Sept2 and their regulatory small GTPases, RhoA and Cdc42, respectively, to the cleavage furrow during the final stages of cytokinesis. We suggest that EPLIN may function during cytokinesis to maintain local accumulation of key cytokinesis proteins at the furrow.

机译：细胞质分裂涉及两个阶段：（1）膜进入，然后（2）膜脱落。进入阶段产生卵裂沟，这需要肌动蛋白-肌球蛋白II收缩环和septin细丝的协同功能。我们证明肌动蛋白结合蛋白，EPLIN，位于胞质分裂过程中的分裂沟，这可能是通过与收缩环成分，肌球蛋白II和septin，Sept2缔合。 EPLIN的耗尽导致形成多核细胞，这与活性肌球蛋白II（MRLC（S19））和Sept2及其调节性小GTPases，RhoA和Cdc42的低效积累在胞质分裂的最后阶段分裂成沟有关。。我们建议EPLIN可能在胞质分裂过程中发挥功能，以维持关键胞质分裂蛋白在沟中的局部积累。

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《Cell cycle》 |2009年第5期|共8页
作者
Chircop M; Oakes V; Graham ME; Ma MP; Smith CM; Robinson PJ; Khanna KK;
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正文语种 eng
中图分类细胞生物学;
关键词
Actins; Cell Line; Tumor; Cytokinesis; Cytoskeletal Proteins; Hela Cells; 肌动蛋白类; 细胞支架蛋白质类; HeLa细胞; 磷酸单脂水解酶类;

机译：Actins;Cell Line;Tumor;Cytokinesis;Cytoskeletal Proteins;Hela Cells;肌动蛋白类;细胞支架蛋白质类;HeLa细胞;磷酸单脂水解酶类;

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1. ATP和钾离子对肌动蛋白与前纤维蛋白结合的影响及其在植物肌动蛋白纯化中的应用 [J] . 易克喜, 陶志华, 任海云植物学报（英文版） . 2001,第007期
2. The actin-binding and bundling protein, EPLIN, is required for cytokinesis. [J] . Chircop M, Oakes V, Graham ME, Cell cycle . 2009,第5期

机译：肌动蛋白结合和捆绑蛋白EPLIN是胞质分裂所必需的。
3. Inhibition of anchorage-independent growth of transformed NIH3T3 cells by epithelial protein lost in neoplasm (EPLIN) requires localization of EPLIN to actin cytoskeleton [J] . Song YH., Maul RS., Gerbin CS., Molecular biology of the cell . 2002,第4期

机译：肿瘤中丢失的上皮蛋白（EPLIN）对转化的NIH3T3细胞锚定非依赖性生长的抑制需要将EPLIN定位于肌动蛋白细胞骨架
4. Recovery from DNA Damage-induced G2 Arrest Requires Actin-binding Protein Filamin-A/Actin-binding Protein 280* [J] . Xiangbing Meng, Yuan Yuan, Adrian Maestas, The Journal of biological chemistry . 2004,第7期

机译：从DNA损伤诱导的G2逮捕中恢复需要肌动蛋白结合蛋白Filamin-A /肌动蛋白结合蛋白280 *
5. EFFECTS OF MECHANICAL STRAIN ON STRUCTURAL AND ACTIN-BINDING PROTEINS IN NEUROBLASTS [C] . Szu-Yuan Chou, Chao-Min Cheng, Yi-Wen Lin, ASME summer bioengineering conference;SBC2009 . 2009

机译：机械应变对神经母细胞结构和肌动蛋白结合蛋白的影响
6. Structural Studies of Actin-Binding Proteins Involved in Actin Dynamics, Organization, and Force Sensing [D] . Huehn, Andrew Robert. 2020

机译：参与肌动蛋白动态，组织和力传感的肌动蛋白结合蛋白的结构研究
7. Inhibition of Anchorage-independent Growth of Transformed NIH3T3 Cells by Epithelial Protein Lost in Neoplasm (EPLIN) Requires Localization of EPLIN to Actin Cytoskeleton [O] . Yuhong Song, Raymond S. Maul, C. Sachi Gerbin, 2002

机译：肿瘤上皮蛋白丢失（EPLIN）对转化的NIH3T3细胞锚定非依赖性生长的抑制需要将EPLIN定位于肌动蛋白细胞骨架
8. Inhibition of Anchorage-independent Growth of Transformed NIH3T3 Cells by Epithelial Protein Lost in Neoplasm (EPLIN) Requires Localization of EPLIN to Actin Cytoskeleton [O] . Song, Yuhong, Maul, Raymond S., Gerbin, C. Sachi, 2002

机译：肿瘤上皮蛋白丢失（EPLIN）对转化的NIH3T3细胞锚定非依赖性生长的抑制，需要将EPLIN定位于肌动蛋白细胞骨架

The actin-binding and bundling protein, EPLIN, is required for cytokinesis.

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