...
首页> 外文期刊>Cell cycle >Tumor metabolism: hnRNP proteins get in on the act.
【24h】

Tumor metabolism: hnRNP proteins get in on the act.

机译:肿瘤代谢:hnRNP蛋白起作用。

获取原文
获取原文并翻译 | 示例
           

摘要

A long observed attribute of tumor cells, which sets them apart from most normal cells, is a high uptake of glucose. The glucose subsequently enters the glyco-lytic pathway and is converted to lactate, even in the presence of oxygen. This phenomenon, known as aerobic glycolysis,1 is thought to allow growing cells to use glycolytic intermediates for biosynthetic processes critical for proliferation. The glycolytic phenotype of cells hinges on the fate of pyruvate, the intermediate converted to lactate in cancer cells, but enters the mitochondria to fuel oxidative phos-phorylation in resting cells.
机译:长期以来观察到的肿瘤细胞属性使葡萄糖与大多数正常细胞区分开,这使它们与大多数正常细胞区分开。葡萄糖随后进入糖酵解途径,甚至在存在氧气的情况下也被转化为乳酸。这种现象被称为有氧糖酵解1,被认为可以使生长中的细胞将糖酵解中间体用于对增殖至关重要的生物合成过程。细胞的糖酵解表型取决于丙酮酸的命运,丙酮酸酯的命运在癌细胞中转变为乳酸,但进入线粒体以促进静止细胞中的氧化磷酸化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号