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首页> 外文期刊>Cell cycle >Vitamin D: Proteases, protease inhibitors and cancer.
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Vitamin D: Proteases, protease inhibitors and cancer.

机译：维生素D：蛋白酶，蛋白酶抑制剂和癌症。

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摘要

The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3), Calcitriol) is a major regulator of gene expression in higher organisms. Protein abundance is an endpoint of gene expression that results from the balance between induction and degradation and is essential for adequate cell function. Proteins are degraded by proteases whose activity is in turn controlled by a number of endogenous protease inhibitors. 1,25(OH)(2)D(3) regulates several proteases and protease inhibitors in different cell types, putatively contributing to its regulatory effects of cell physiology. We have recently shown that 1,25(OH)(2)D(3) strongly induces the expression of cystatin D, an inhibitor of several cysteine proteases of the cathepsin family. Cystatin D induction may contribute to the antitumor effect of 1,25(OH)(2)D(3) against colon cancer by mechanisms that are both dependent and independent of cathepsin inhibition. Transcriptomic studies suggest that 1,25(OH)(2)D(3) also modulates the function of the ubiquitin-proteasome system. Thus, proteases and protease inhibitors are candidates to mediate to a certain extent the complex action of 1,25(OH)(2)D(3) in cancer cells.
机译：活性维生素D代谢物1alpha，25-dihydroxyvitamin D（3）（1,25（OH）（2）D（3），Calcitriol）是高等生物中基因表达的主要调节剂。蛋白质丰度是诱导和降解之间平衡的结果，是基因表达的终点，并且对于细胞的充分功能至关重要。蛋白质被蛋白酶降解，其活性又受许多内源性蛋白酶抑制剂控制。 1,25（OH）（2）D（3）在不同的细胞类型中调节几种蛋白酶和蛋白酶抑制剂，推测有助于其对细胞生理的调节作用。我们最近显示1,25（OH）（2）D（3）强烈诱导胱抑素D的表达，胱抑素D是组织蛋白酶家族中几种半胱氨酸蛋白酶的抑制剂。胱抑素D诱导可能通过依赖和独立于组织蛋白酶抑制的机制来促进1,25（OH）（2）D（3）对结肠癌的抗肿瘤作用。转录组学研究表明1,25（OH）（2）D（3）也调节泛素-蛋白酶体系统的功能。因此，蛋白酶和蛋白酶抑制剂是在一定程度上介导癌细胞中1,25（OH）（2）D（3）的复杂作用的候选者。

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