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The CINSARC signature: prognostic and predictive of response to chemotherapy?

机译:CINSARC的特征:对化疗反应的预后和预测?

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摘要

Soft tissue sarcomas (STS) are a heterogeneous group of rare malignant tumors predominantly arising from the embryonic mesoderm. Surgery is the main treatment for early stage STS in adult patients. During the last decades, advances concerned the local control of disease and limb preservation with more conservative surgeries combined with adjuvant radiotherapy. But up to 50% of patients develop distant metastases during the course of their disease, to which they succumb in most cases. No significant progress has been observed regarding metastasis-free and overall survivals, and the benefit of adjuvant chemotherapy, based on an anthracycline/ifosfamide combination, remains limited,1 making its use controversial.
机译:软组织肉瘤(STS)是罕见的恶性肿瘤的异质性组,主要来自胚胎中胚层。手术是成人患者早期STS的主要治疗方法。在过去的几十年中,进展涉及局部疾病的控制和四肢保守性的保护以及更保守的手术结合辅助放疗。但是,多达50%的患者在病程中会发生远处转移,在大多数情况下他们会屈服。在无转移和总体生存方面未观察到重大进展,基于蒽环类/异环磷酰胺组合的辅助化疗的益处仍然有限,1使其使用引起争议。

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