Regulation of vitamin metabolism by p53 and p63 in development and cancer.

Zhou H; van Bokhoven H

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Regulation of vitamin metabolism by p53 and p63 in development and cancer.

机译：p53和p63在发育和癌症中对维生素代谢的调节。

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Vitamin A and its derivatives have been long implicated in development and tumor suppression. The major active derivative of vitamin A, retinoic acid (RA), has been shown to regulate major embryonic growth and patterning decision in vertebrates. Pioneering studies by Josef Warkany and others in the 1940's and 50's established the key role of vitamin A during fetal development in rats. By now vitamin A metabolites have been implicated in a plethora of cellular processes, such as cell differentiation, apoptosis and proliferative potential of progenitor cells in organ development and in the maintenance of various epithelia.' In addition, there are several lines of evidence that have revealed an important role of vitamin A in tumor prevention or suppression. These effects of vitamin A in development and tumor suppression show some striking parallels with the function of p53 gene family members.

机译：长期以来，维生素A及其衍生物与发展和肿瘤抑制有关。维生素A的主要活性衍生物维甲酸（RA）已显示出可调节脊椎动物的主要胚胎生长和模式决定。约瑟夫·沃卡尼（Josef Warkany）等人在1940年代和50年代的开创性研究确立了维生素A在大鼠胎儿发育过程中的关键作用。到目前为止，维生素A代谢产物已参与多种细胞过程，例如器官分化和各种上皮的维持过程中祖细胞的细胞分化，凋亡和增殖潜能。此外，有几条证据表明维生素A在预防或抑制肿瘤中具有重要作用。维生素A在发育和肿瘤抑制中的这些作用与p53基因家族成员的功能有一些惊人的相似之处。

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《Cell cycle》 |2010年第14期|共1页
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Zhou H; van Bokhoven H;
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正文语种 eng
中图分类细胞生物学;
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1. Differential effects of p63 mutants on transactivation of p53 and/or p63 responsive genes [J] . Shama K Khokhar, Ramakrishna Kommagani, Madhavi P Kadakia 细胞研究（英文版） . 2008,第010期
2. Differential effects of p63 mutants on transactivation of p53 and/or p63 responsive genes [J] . Shama K Khokhar, Ramakrishna Kommagani, Madhavi P Kadakia 细胞研究：英文版 . 2008,第010期
3. Regulation of vitamin metabolism by p53 and p63 in development and cancer. [J] . Zhou H, van Bokhoven H Cell cycle . 2010,第14期

机译：p53和p63在发育和癌症中对维生素代谢的调节。
4. Positive and negative regulation of |[Delta]|N-p63 promoter activity by p53 and |[Delta]|N-p63-|[alpha]| contributes to differential regulation of p53 target genes [J] . David Christopher Harmes, Edward Bresnick, Emma A Lubin, Oncogene . 2003,第48期

机译：p53和|Δ| N-p63- |α|对|Δ| N-p63启动子活性的正负调节。有助于p53靶基因的差异调控
5. REDD1, a Developmentally Regulated Transcriptional Target of p63 and p53, Links p63 to Regulation of Reactive Oxygen Species [J] . Leif W. Ellisen, Kate D. Ramsayer, Cory M. Johannessen, Molecular cell . 2002,第5期

机译：REDD1是p63和p53的发育调控转录靶标，将p63与活性氧物种的调控联系起来。
6. Regulation of CYP enzymes in steroidogenesis with particular focus on cholesterol metabolism and vitamin D-related processes [C] . Wikvall K., Ellfolk M., Tang W., International Conference on Cytochrome P450 . 2009

机译：特别关注胆固醇代谢和维生素D相关过程的甾醇中CYP酶的调节
7. Differential regulation of vitamin D receptor (VDR) by p53, p63 and p73. [D] . Kommagani, Ramakrishna. 2009

机译：p53，p63和p73对维生素D受体（VDR）的差异调节。
8. TAp63γ and ΔNp63β Promote Osteoblastic Differentiation of Human Mesenchymal Stem Cells: Regulation by Vitamin D3 Metabolites [O] . Kevin M. Curtis, Kristina K. Aenlle, Rachel N. Frisch, -1

机译：TAp63γ和ΔNp63β促进人间充质干细胞成骨细胞分化：维生素D3代谢产物的调节。
9. TAp63γ and ΔNp63β promote osteoblastic differentiation of human mesenchymal stem cells: regulation by vitamin D3 Metabolites. [O] . Kevin M Curtis, Kristina K Aenlle, Rachel N Frisch, 2015

机译：Tap63γ和ΔNp63β促进人间充质干细胞的成骨细胞分化：维生素D3代谢物的调节。
10. Vitamin A Regulation of Cadherins in Breast Cancer. [R] . Pishvaian, M., Byers, S. 2000

机译：维生素a对乳腺癌中钙粘蛋白的调节作用。

Regulation of vitamin metabolism by p53 and p63 in development and cancer.

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