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Long-term results of photodynamic therapy of polypoidal choroidal vasculopathy.

机译:息肉样脉络膜血管病变的光动力治疗的长期结果。

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PURPOSE: This study evaluated the results of photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV) 24 months or more after treatment. METHODS: The study involved 47 eyes of 47 patients with PCV followed for 24 months or more after the first PDT. Fundus appearance, indocyanine green angiographic findings, and visual acuity (VA) were compared before PDT, and then at 3 months, 12 months, and the final visit after the first PDT. RESULTS: At the final visit, VA was preserved or improved in 37 (79%) of the 47 eyes. Recurrence of polypoidal lesions was noted in 30 eyes (64%). An abnormal branching vascular network persisted in all subjects. In 26 of the 30 eyes exhibited recurrence of polypoidal lesions, which appeared in the periphery of the expanded abnormal branching vascular network. CONCLUSION: Patients with PCV need to be followed for long periods of time after PDT because of the high incidence of polypoidal lesion recurrence. However, since polypoidal lesions often recur outside the fovea, and thus have little effect on VA, PDT can be expected to exert long-term efficacy in treating PCV.
机译:目的:本研究评估了治疗后24个月或更长时间的光动力疗法(PDT)对多发性脉络膜脉络膜血管病(PCV)的结果。方法:该研究涉及47例PCV患者的47眼,首次PDT后随访了24个月或更长时间。在PDT之前,然后在3个月,12个月以及第一次PDT之后的最后访视时,比较眼底外观,吲哚菁绿血管造影结果和视敏度(VA)。结果:在最后一次访视时,47眼中的37眼(79%)VA得以保留或改善。在30只眼中发现息肉样病变的复发(64%)。在所有受试者中均存在异常分支血管网络。 30只眼睛中有26只表现出息肉样病变复发,出现在扩大的异常分支血管网络的外围。结论:PDV后多发性病变复发的发生率很高,因此需要长期随访PCV患者。但是,由于息肉样病变通常会在中央凹以外复发,因此对VA的影响很小,因此可以预期PDT在治疗PCV方面具有长期疗效。

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