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首页> 外文期刊>Retina >Clinical and microbiologic review of culture-proven endophthalmitis caused by multidrug-resistant bacteria in patients seen at a tertiary eye care center in southern India.
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Clinical and microbiologic review of culture-proven endophthalmitis caused by multidrug-resistant bacteria in patients seen at a tertiary eye care center in southern India.

机译：在印度南部的三级眼保健中心，对由多药耐药性细菌引起的培养证实的眼内炎进行临床和微生物学审查。

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PURPOSE: To determine the type of bacteria and the visual outcome of culture-proven multidrug-resistant bacterial endophthalmitis in patients at a tertiary eye care center in southern India. METHODS: This is a retrospective case series in which clinical and microbiologic records of culture-proven bacterial endophthalmitis between January 2000 and December 2007 were reviewed. Multidrug resistance was defined as resistance to two or more different groups of typically susceptible classes of antibiotics. RESULTS: Of 807 patients, vitreous from 42 patients (5.2%) yielded multidrug-resistant bacteria in culture. Thirty-two (71%) of these patients had a poor visual outcome (31.6% in non-multidrug-resistant group). Multidrug resistance was more common in gram-negative bacteria (33; 78.6%) compared with gram-positive bacteria (9; 21.4%). Pseudomonas spp. (24 isolates) were the most common isolated bacteria. Fifteen (45%) of the 33 gram-negative isolates were resistant to ceftazidime, 18 (54.5%) were resistant to amikacin, and 11 (33.3%) were resistant to both amikacin and ceftazidime. Five (55.56%) of the 9 gram-positive isolates were resistant to vancomycin. CONCLUSION: Gram-negative bacteria, chiefly Pseudomonas, are the most common multidrug-resistant organisms, and the outcome is usually poor. Emergence of multidrug-resistant bacteria is a matter of concern. A new alternative group of drugs may be considered for the management of these isolated cases.
机译：目的：在印度南部的一家三级眼保健中心，确定细菌的种类以及经过培养证明的耐多药细菌性眼内炎的视觉效果。方法：这是一个回顾性病例系列，其中回顾了2000年1月至2007年12月间培养证实的细菌性眼内炎的临床和微生物学记录。多药耐药性定义为对两组或多组不同类别的典型易感抗生素具有耐药性。结果：在807例患者中，有42例患者的玻璃体（5.2％）在培养物中产生了多药耐药菌。这些患者中有三十二名（71％）的视觉结果较差（非多药耐药组为31.6％）。与革兰氏阳性菌（9; 21.4％）相比，革兰氏阴性菌（33; 78.6％）的多药耐药性更为普遍。假单胞菌（24株）是最常见的分离细菌。 33克阴性菌中有15株（45％）对头孢他啶有抗药性，18株（54.5％）对丁胺卡那霉素有抗药性，11株（33.3％）对丁胺卡那霉素和头孢他啶有抗药性。 9克阳性分离株中有5个（55.56％）对万古霉素有抗药性。结论：革兰氏阴性细菌，主要是假单胞菌，是最常见的耐多药生物，其结果通常较差。多药耐药细菌的出现是一个令人关注的问题。可以考虑使用新的替代药物组来管理这些孤立的病例。

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