The power of chemotherapeutic engineering: arresting cell cycle and suppressing senescence to protect from mitotic inhibitors.

Blagosklonny MV

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The power of chemotherapeutic engineering: arresting cell cycle and suppressing senescence to protect from mitotic inhibitors.

机译：化疗工程的力量：阻止细胞周期并抑制衰老，以保护细胞免受有丝分裂抑制剂的侵害。

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Suppose one drug causes lethal mitotic arrest, another treatment causes irreversible senescence and a third drug inhibits cellular mass growth: Could cells treated with a combination of all three agents magically emerge alive and proliferating? The result of this experiment is presented here. By knowing the mechanisms of cell cycle arrest, death and senescence, we can design "rainbow combinations" that obediently kill or spare desired cells. Knowledge is power.

机译：假设一种药物引起致命的有丝分裂阻滞，另一种药物引起不可逆的衰老，而第三种药物抑制细胞团的生长：用这三种药物联合治疗的细胞能否神奇地存活并增殖？此实验的结果在此处显示。通过了解细胞周期停滞，死亡和衰老的机制，我们可以设计顺服地杀死或保留所需细胞的“彩虹组合”。知识就是力量。

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《Cell cycle》 |2011年第14期|共4页
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Blagosklonny MV;
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正文语种 eng
中图分类细胞生物学;
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1. The power of chemotherapeutic engineering: arresting cell cycle and suppressing senescence to protect from mitotic inhibitors. [J] . Blagosklonny MV Cell cycle . 2011,第14期

机译：化疗工程的力量：阻止细胞周期并抑制衰老，以保护细胞免受有丝分裂抑制剂的侵害。
2. A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification [J] . Xu Bo, Deng Yuyou, Bi Ran, Cancer chemotherapy and pharmacology. . 2018,第6期

机译：通过抑制UBE2M依赖性的Neddylation改性，诱导人肾细胞癌中诱导细胞周期停滞，衰老和细胞凋亡的一类抑制剂
3. Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest [J] . Dina Dikovskaya, John?J. Cole, Susan?M. Mason, Cell Reports . 2015,第9期

机译：有丝分裂应激是致癌基因诱导衰老程序的一个组成部分，该程序促进多核化和细胞周期阻滞。
4. AUTOMATED MICROSCOPY SCREEN TO IDENTIFY COMPONENTS REQUIRED FOR MITOTIC CELL CYCLE PROGRESSION IN HUMAN CELLS [C] . Rines, D.R., Gomez, . 2007

机译：自动显微镜屏幕识别人细胞中有丝分裂细胞周期所需的成分
5. Dietary isothiocyanates suppress microtubule dynamic instability in association with mitotic arrest and inhibition of tumor cell proliferation. [D] . Azarenko, Olga. 2009

机译：饮食中的异硫氰酸盐抑制与有丝分裂停滞和抑制肿瘤细胞增殖相关的微管动态不稳定性。
6. Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest [O] . Dina Dikovskaya, John J. Cole, Susan M. Mason, -1

机译：有丝分裂应激是致癌基因诱导衰老程序的一个组成部分该程序促进多核化和细胞周期阻滞。
7. Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest [O] . Dina Dikovskaya, John J. Cole, Susan M. Mason, 2015

机译：有丝分裂应激是癌基因诱导的衰老计划的一个组成部分，促进多核和细胞周期逮捕

The power of chemotherapeutic engineering: arresting cell cycle and suppressing senescence to protect from mitotic inhibitors.

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