Chromatin is regulated by modifications of the DNA and of histone proteins. These modifications provide docking sites for proteins that contain specific recognition domains. Many of these proteins function as enzymes which modify chromatin or remodel nucleosomes, or act as recruiters of complexes containing such activities. Combining the large number of modifications that exist generates a "modification landscape" that can be read by such proteins. Understanding how proteins selectively recognize the modification landscape will help us understand how different chromatin environments can control DNA function.
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