• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular Physiology and Biochemistry >Vinpocetine inhibits oligodendroglial precursor cell differentiation
【24h】

Vinpocetine inhibits oligodendroglial precursor cell differentiation

机译：长春西汀抑制少突胶质前体细胞分化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: In multiple sclerosis during periods of remission a limited degree of myelin repair can be observed mediated by oligodendroglial precursor cells. Phosphodiesterase inhibitors act as anti-inflammatory agents and might hold promise for future multiple sclerosis treatment. Aims: To investigate whether phosphodiesterase inhibitors could also influence myelin repair. Methods: We stimulated primary oligodendroglial precursor cells with cilostazol, rolipram and vinpocetine and assessed their effects on repair related cellular processes. Results: We found that vinpocetine exerted a strong negative effect on myelin expression while cilostazol and rolipram did not show such effects. In addition, vinpocetine decreased morphological complexities suggesting an overall negative impact on oligodendroglial cell maturation. We provide evidence that this is not mediated via a blockade of phosphodiesterase-1 but rather by inhibition of IκB kinase. Conclusion: These findings suggest that vinpocetine via IκB inhibition exerts a strong negative impact on oligodendroglial cell maturation and may therefore provide the rationale to restrict its application during periods of remission in multiple sclerosis patients. This is of particular interest since vinpocetine is widely used as a health supplement thought to act as a cognitive and memory enhancer for healthy people and patients with neurological or muscle diseases.
机译：背景：在缓解期的多发性硬化症中，可以观察到少突胶质前体细胞介导的髓鞘修复程度有限。磷酸二酯酶抑制剂可作为抗炎药，并有望在未来的多发性硬化症治疗中发挥作用。目的：研究磷酸二酯酶抑制剂是否也可能影响髓鞘修复。方法：我们用西洛他唑，咯利普兰和长春西汀刺激了少突胶质前体细胞，并评估了它们对修复相关细胞过程的影响。结果：我们发现长春西汀对髓磷脂的表达产生强烈的负面影响，而西洛他唑和咯利普兰没有这种作用。此外，长春西汀降低了形态复杂性，提示对少突胶质细胞成熟有整体负面影响。我们提供的证据表明，这不是通过磷酸二酯酶-1的阻断来介导的，而是通过抑制IκB激酶来介导的。结论：这些发现表明，长春西汀通过IκB抑制作用对少突胶质细胞成熟具有强烈的负面影响，因此可能为限制其在多发性硬化症患者缓解期间的应用提供了理论依据。这是特别令人感兴趣的，因为长春西汀被广泛用作健康补充剂，被认为可以充当健康人和神经系统疾病或肌肉疾病患者的认知和记忆增强剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号