...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >Checkpoint kinase-1: One actor playing two roles in 'maintaining genomic integrity'
【24h】

Checkpoint kinase-1: One actor playing two roles in 'maintaining genomic integrity'

机译：Checkpoint激酶-1：一位演员在“维持基因组完整性”中扮演两个角色

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Checkpoint kinase-1 (CHK1) is well known for its role as the effector kinase in the ATR-CHK1-CDC25 DNA damage response, a key pathway in maintaining genomic integrity. CHK1 is activated by the "ATM and Rad3-related" (ATR) kinase in response to stalled replication forks, bulky lesions and single-strand DNA breaks. Activated CHK1 then inactivates CDC25, the protein phosphatase that converts cyclin-dependent kinase-1 (CDK1) into its active form. Thus, CHK1 prevents CDK1 from driving cells with damaged or incompletely replicated DNA into mitosis. However, CHK1 is essential for cell viability, and suppression of CHK1 activity can result in unscheduled DNA replication that induces DNA damage, suggesting that CHK1 is also active during normal mitotic cell cycles.
机译：Checkpoint激酶1（CHK1）以其在ATR-CHK1-CDC25 DNA损伤反应中的效应激酶的作用而闻名，这是维持基因组完整性的关键途径。 CHK1被“ ATM和Rad3相关”（ATR）激酶激活，以响应停滞的复制叉，大体积病变和单链DNA断裂。然后，活化的CHK1使CDC25失活，CDC25是一种蛋白磷酸酶，可将细胞周期蛋白依赖性激酶1（CDK1）转化为其活性形式。因此，CHK1阻止CDK1将DNA受损或复制不完全的细胞驱动到有丝分裂中。但是，CHK1对于细胞活力至关重要，抑制CHK1活性可能导致计划外的DNA复制，从而导致DNA损伤，这表明CHK1在正常的有丝分裂细胞周期中也具有活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号