• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular Physiology and Biochemistry >Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: Is DCA a suitable drug for neuroblastoma therapy?
【24h】

Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: Is DCA a suitable drug for neuroblastoma therapy?

机译：二氯乙酸盐（DCA）对神经母细胞瘤细胞中乳酸生成和耗氧量的影响：DCA是否适合用于神经母细胞瘤治疗？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Many cancer cells metabolize glucose preferentially via pyruvate to lactate instead to CO _2 and H _2O (oxidative phosphorylation) even in the presence of oxygen (Warburg effect). Dichloroacetate (DCA) is a drug which is able to shift pyruvate metabolism from lactate to acetyl-CoA (tricarboxylic acid cycle) by indirect activation of pyruvate dehydrogenase (PDH). This can subsequently lead to an increased flow of oxygen in the respiratory chain, associated with enhanced generation of reactive oxygen species (ROS) which may cause apoptosis. In order to investigate if DCA may be suitable for neuroblastoma therapy, it was investigated on three human neuroblastoma cell lines whether DCA can reduce lactate production and enhance oxygen consumption. The data show, that DCA (in the low millimolar range) is able to reduce lactate production, but there was only a slight shift to increased oxygen consumption and almost no effect on cell vitality, proliferation and apoptosis of the three cell lines investigated. Therefore, DCA at low millimolar concentrations seems to be only of minor efficacy for neuroblastoma treatment.
机译：即使在存在氧气的情况下，许多癌细胞也优先通过丙酮酸将葡萄糖代谢为乳酸，而不是CO 2和H _2O（氧化磷酸化）（Warburg效应）。二氯乙酸盐（DCA）是一种能够通过间接激活丙酮酸脱氢酶（PDH）将丙酮酸代谢从乳酸转变为乙酰辅酶A（三羧酸循环）的药物。随后，这会导致呼吸链中氧气的流量增加，从而增加活性氧（ROS）的产生，从而导致细胞凋亡。为了研究DCA是否适合神经母细胞瘤治疗，在三种人类神经母细胞瘤细胞系上研究了DCA是否可以减少乳酸生成并增加耗氧量。数据表明，DCA（在低毫摩尔范围内）能够减少乳酸的产生，但是增加的耗氧量只有很小的变化，并且对所研究的三种细胞系的细胞活力，增殖和凋亡几乎没有影响。因此，低毫摩尔浓度的DCA似乎对神经母细胞瘤的治疗效果不佳。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号