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Tachykinin family genes and their receptors are differentially expressed in the hypothyroid ovary and pituitary

机译：速激肽家族基因及其受体在甲状腺功能减退的卵巢和垂体中差异表达

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Plasma tachykinin levels are known to be altered with sexual acyclicity and loss of reproductive function. Ovulatory dysfunction, as seen in postmenopausal women, is also often encountered in hypothyroid patients. To know the involvement of different tachykinin genes in hypothyroidism-associated reproductive disorders, we performed DD-PCR with the pituitary RNA of control and hypothyroid rats to see the differentially expressed gene profile. Subsequently, we selected a few clones, tachykinin being one of them. Since its expression was up regulated in hypothyroidism as it does in the sexually acyclic females, we wanted to correlate these two phenomena with hypothyroidism associated reproductive disorders. We observed differential expression of tac2 along with other tk genes and their receptors in rat pituitary and ovary, which suggests that hypothyroidism affects the expression of these genes in these tissues. The experiments were repeated in ovarian tissue obtained at surgery from hypothyroid human patients, which showed similar expression pattern of TAC3 (equivalent to rat tac2) and their receptors as in rat ovary. Significant reduction of tac2 expression in reproductively less active rat ovary suggests the association of tac2 with reproductive senescence. Our results suggest that decline in reproductive function in hypothyroidism is associated with altered expression level of tac2 and its receptors. Further investigation in this area could elucidate the possible mechanism of tachykinins' involvement in loss of sexual cyclicity and other reproductive disorders associated with hypothyroidism. Copyright (c) 2007 S. Karger AG, Basel.
机译：已知血浆速激肽水平会随着性无环性和生殖功能的丧失而改变。如绝经后妇女所见，排卵功能障碍也常发生在甲状腺功能减退患者中。为了了解不同的速激肽基因参与甲状腺功能减退相关的生殖疾病，我们用对照和甲状腺功能减退大鼠的垂体RNA进行了DD-PCR，以观察差异表达的基因谱。随后，我们选择了几个克隆，速激肽就是其中之一。由于其表达在甲状腺功能减退症中像在无性循环的女性中一样被上调，因此我们希望将这两种现象与甲状腺功能减退症相关的生殖障碍相关联。我们观察到tac2与其他tk基因及其受体在大鼠垂体和卵巢中的差异表达，这表明甲状腺功能减退会影响这些基因在这些组织中的表达。在甲状腺功能低下的人类患者的手术卵巢组织中重复了该实验，结果显示TAC3（相当于大鼠tac2）及其受体的表达模式与大鼠卵巢相似。生殖活性较低的大鼠卵巢中tac2表达的显着降低表明tac2与生殖衰老有关。我们的结果表明，甲状腺功能减退症的生殖功能下降与tac2及其受体的表达水平改变有关。在这一领域的进一步研究可以阐明速激肽参与性功能丧失和与甲状腺功能减退有关的其他生殖疾病的可能机制。版权所有（c）2007 S.Karger AG，巴塞尔。

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