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首页> 外文期刊>Respiratory medicine >Nasal nitric oxide for early diagnosis of primary ciliary dyskinesia: practical issues in children.
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Nasal nitric oxide for early diagnosis of primary ciliary dyskinesia: practical issues in children.

机译：鼻一氧化氮用于原发性睫状运动障碍的早期诊断：儿童的实际问题。

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BACKGROUND: Primary ciliary dyskinesia (PCD) is a genetic disease characterized by abnormally beating cilia. In these patients, levels of nasal nitric oxide (nNO) are lower than those observed in healthy subjects. OBJECTIVES: We identify the nNO levels in healthy pre-school uncooperative children and in PCD patients, in order the application of nNO measurement in the early identification of young children with PCD. METHODS: We measured nNO in 77 healthy children (50 uncooperative and 27 cooperative) and in 10 PCD patients. Fifteen cooperative healthy children were also asked to perform an uncooperative test. RESULTS: PCD patients presented low nNO levels (29.7+/-5.7 ppb) compared to those observed in healthy children (358.8+/-35.2 ppb; p<0.05). nNO levels were increased in healthy cooperative children (650+/-60.6 ppb; p<0.05) as compared to those uncooperative aging more than 6 month (309.1+/-45.9 ppb; p<0.05) or less (128.1+/-16.2 ppb; p<0.05). Twenty-four uncooperative children with nNO values < or =200 ppb performed a second evaluation at least 6 months later and mean levels increased from 104.7+/-10.5 ppb to 169.9+/-19.6 ppb (p<0.05). In the 15 collaborative children nNO levels were higher during the breath holding manoeuvre (687.7+/-96.9 ppb) than during the tidal breathing manoeuvre (335.9+/-57.9 ppb; p<0.05). CONCLUSIONS: Healthy children have higher nNO levels than PCD patients. In 15% of uncooperative healthy children can be found low nNO levels, similar to PCD patients, but those values increased some months later, in successive evaluations. Nasal NO may be used for PCD screening even though repeated evaluations may be necessary in young children.
机译：背景：原发性睫状运动障碍（PCD）是一种以异常跳动纤毛为特征的遗传疾病。在这些患者中，一氧化氮（nNO）的水平低于健康受试者中观察到的水平。目的：我们确定健康的学龄前不合作儿童和PCD患者中的nNO水平，以便将nNO测量应用于早期识别PCD幼儿中。方法：我们测量了77名健康儿童（50名不合作和27名合作儿童）和10名PCD患者的nNO。还要求15名合作健康儿童进行不合作测试。结果：与健康儿童（358.8 +/- 35.2 ppb; p <0.05）相比，PCD患者的nNO水平较低（29.7 +/- 5.7 ppb）。与不合作年龄超过6个月以上（309.1 +/- 45.9 ppb; p <0.05）或更小（128.1 +/- 16.2）的健康合作儿童相比，nNO水平升高（650 +/- 60.6 ppb; p <0.05） ppb; p <0.05）。 nNO值≤200 ppb的二十四个不合作的儿童至少在六个月后进行了第二次评估，平均水平从104.7 +/- 10.5 ppb增加到169.9 +/- 19.6 ppb（p <0.05）。在15名协作儿童中，屏气操作期间的nNO水平较高（687.7 +/- 96.9 ppb），而潮气呼吸操作期间的nNO水平较高（335.9 +/- 57.9 ppb; p <0.05）。结论：健康儿童的nNO水平高于PCD患者。在15％不合作的健康儿童中，发现nNO水平较低，类似于PCD患者，但在连续评估中，这些值在几个月后有所增加。鼻NO可用于PCD筛查，即使在幼儿中可能需要反复评估。

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