Ras/Raf/ERK signalling and NF1.

Harrisingh MC; Lloyd AC

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Ras/Raf/ERK signalling and NF1.

机译：Ras / Raf / ERK信号传导和NF1。

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Ras signalling is important in the development of Schwann-cell-derived tumors in Neurofibromatosis Type 1 (NF1) patients. Schwann cells are a regenerative cell type, with no known stem-cell population. To produce new cells in the adult, for example following nerve damage, myelinating Schwann cells de-differentiate, proliferate and then re-differentiate during the repair process. We have found that Ras/Raf/ERK signalling can drive the de-differentiation of myelinated Schwann cells. In this review, we discuss how our results may contribute to the understanding of tumor formation in NF1 patients.

机译：Ras信号在1型神经纤维瘤病（NF1）患者的雪旺细胞衍生肿瘤的发展中很重要。雪旺氏细胞是再生细胞类型，没有已知的干细胞群体。为了在成人中产生新细胞，例如在神经损伤后，有髓鞘的雪旺氏细胞在修复过程中去分化，增殖然后再分化。我们已经发现，Ras / Raf / ERK信号传导可以驱动髓鞘雪旺细胞的去分化。在这篇综述中，我们讨论了我们的结果如何有助于理解NF1患者的肿瘤形成。

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《Cell cycle》 |2004年第10期|共4页
作者
Harrisingh MC; Lloyd AC;
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正文语种 eng
中图分类细胞生物学;
关键词
Extracellular Signal-Regulated MAP Kinases; Neurofibromin 1; Oncogene Proteins v-raf;

机译：细胞外信号调节的MAP激酶;神经纤维蛋白1;癌基因蛋白v-raf;

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专利

1. Ras/Raf/ERK signalling and NF1. [J] . Harrisingh MC, Lloyd AC Cell cycle . 2004,第10期

机译：Ras / Raf / ERK信号传导和NF1。
2. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF [J] . Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag, Nature . 2010,第7287期

机译：RAF抑制剂可在野生型BRAF细胞中激活RAF二聚体和ERK信号转导
3. RAF Inhibitor-Induced KSR1/B-RAF Binding and Its Effects on ERK Cascade Signaling [J] . McKay Melissa M., Ritt Daniel A., Morrison Deborah K. . Current Biology: CB . 2011,第7期

机译：RAF抑制剂诱导的KSR1 / B-RAF结合及其对ERK级联信号的影响
4. COMPLETE EVALUATION OF A PerkinElmer RAFS IN THE GALILEO CONTEXT [C] . Jerome DELPORTE, Michel BRUNEI, Thierry TOURNIER 14th European Frequency and Time Forum (EFTF), Mar 14-16, 2000, Torino (Italy) . 2000

机译：GALILEO环境中PerkinElmer RAFS的完整评估
5. Investigating the role of the mamalian ste-20 like kinase 2 (Mst2) in Raf-1-ERK signaling and in neurofibromatosis type 2 (NF2) cancer syndrome. [D] . Kilili, Geoffrey Kimiti. 2010

机译：调查哺乳动物的Ste20样激酶2（Mst2）在Raf-1-ERK信号传导和2型神经纤维瘤病（NF2）癌症综合征中的作用。
6. Cyclic AMP Signaling Reduces Sirtuin 6 Expression in Non-small Cell Lung Cancer Cells by Promoting Ubiquitin-Proteasomal Degradation via Inhibition of the Raf-MEK-ERK (Raf/Mitogen-activated Extracellular Signal-regulated Kinase/Extracellular Signal-regulated Kinase) Pathway [O] . Eui-Jun Kim, Yong-Sung Juhnn 2015

机译：循环AMP信号传导通过抑制Raf-MEK-ERK（Raf /促分裂原激活的细胞外信号调节激酶/细胞外信号调节激酶）途径促进泛素-蛋白酶体降解从而降低非小细胞肺癌细胞中Sirtuin 6的表达。
7. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF [O] . Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag, 2010

机译：RAF抑制剂用野生型BRAF将RAF二聚体和ERK信号传递转椎体
8. Novel Gbeta Mimic Kelch Proteins (Gpb1 and Gpb2) Connect G-Protein Signaling to Ras via Yeast Neurofibromin Homologs Ira1 and Ira2. A Model for Human NF1. [R] . Heitman, J., Harashima, T. 2007

机译：新型Gbeta mimic Kelch蛋白（Gpb1和Gpb2）通过酵母Neurofibromin同系物Ira1和Ira2将G蛋白信号连接到Ras。人类NF1的模型。

Ras/Raf/ERK signalling and NF1.

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