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首页> 外文期刊>Cell cycle >A genetic oscillator and the regulation of cell cycle progression in Caulobacter crescentus.
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A genetic oscillator and the regulation of cell cycle progression in Caulobacter crescentus.

机译：新月形杆菌中的遗传振荡器和细胞周期进程的调节。

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Analyses of cell polarity, division, and differentiation in prokaryotes have identified several regulatory proteins that exhibit dramatic changes in expression and spatial localization over the course of a cell cycle. The dynamic behavior of these proteins is often intrinsically linked to their function as polarity determinants.(1-3) In the alpha-proteobacterium, Caulobacter crescentus, the CtrA global transcriptional regulator exhibits a spatially and temporally dynamic expression pattern across the cell cycle. CtrA plays key roles in asymmetric cell division and in the timing of chromosome replication.(3,4) An additional global regulator, GcrA, has recently been discovered that both regulates and is regulated by CtrA.(5) Together, these regulatory proteins create a genetic circuit in which the cellular concentrations of CtrA and GcrA oscillate spatially and temporally to control daughter cell differentiation and cell cycle progression.
机译：对原核生物中细胞极性，分裂和分化的分析已鉴定出几种调节蛋白，这些蛋白在细胞周期过程中表现出表达和空间定位的巨大变化。这些蛋白质的动态行为通常与它们作为极性决定因素的功能固有地联系在一起。（1-3）在α-变形杆菌，Caulobacter crescentus中，CtrA全局转录调节子在整个细胞周期内表现出时空动态表达模式。 CtrA在不对称细胞分裂和染色体复制的时机中起着关键作用。（3,4）最近发现了另外一种全局调节剂GcrA，它既调节CtrA并受其控制。（5）这些调节蛋白共同产生一个遗传回路，其中CtrA和GcrA的细胞浓度在空间和时间上振荡，以控制子代细胞分化和细胞周期进程。

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