Micromanaging a large tumor suppressor

LiY.; SpanerD.E.

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Micromanaging a large tumor suppressor

机译：微处理大型肿瘤抑制物

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Studies of microRNA (miRNA) in cancer are relatively recent but have exciting possibilities to improve our understanding and treatment of this disease.1 Over 1,000 miRNAs (1-4% of the human genome) exist in non-coding genes or gene clusters or in introns of coding genes. Primary miRNA transcripts are cleaved into stem-loop structures in the nucleus and trimmed into 19-24 nucleotide duplexes in the cytoplasm. One strand of a duplex is incorporated into an RNA-induced silencing complex (RISC), where it binds complementary sequences in 3'-untranslated regions (UTRs) and decreases protein expression by inhibiting translation or causing mRNA degradation. Each miRNA can potentially bind 200 mRNAs and regulate multiple genetic pathways.

机译：癌症中的microRNA（miRNA）研究相对较新，但有令人振奋的可能性，可以增进我们对这种疾病的理解和治疗。1非编码基因或基因簇或非编码基因中存在1,000多种miRNA（占人类基因组的1-4％）。编码基因的内含子。初级miRNA转录物在细胞核中被切割成茎环结构，并在细胞质中被修饰成19-24个核苷酸双链体。将双链体的一条链掺入RNA诱导的沉默复合体（RISC），在其中它结合3'非翻译区（UTR）中的互补序列，并通过抑制翻译或引起mRNA降解来降低蛋白质表达。每个miRNA可能会结合200个mRNA，并调节多种遗传途径。

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《Cell cycle》 |2012年第24期|共1页
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LiY.; SpanerD.E.;
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1. Micromanaging a large tumor suppressor [J] . LiY., SpanerD.E. Cell cycle . 2012,第24期

机译：微处理大型肿瘤抑制物
2. Alternative exon usage creates novel transcript variants of tumor suppressor SHREW-1 gene with differential tissue expression profile Alternative exon usage creates novel transcript variants of tumor suppressor SHREW-1 gene with differential tissue expression profile Alternative exon usage creates novel transcript variants of tumor suppressor SHREW-1 gene with differential tissue expression profile [J] . Petra A. B. Klemmt, Knut Engels, Eduard Resch, Biology Open . 2016,第11期

机译：替代性外显子用法可产生具有不同组织表达特征的抑癌基因SHREW-1基因的新转录物变体替代性外显子用法可产生具有不同组织表达特征的抑癌基因SHREW-1基因的新转录物变体替代性外显子用法可产生肿瘤抑制物SHREW-1的新型转录物变体1个具有不同组织表达谱的基因
3. Stability of the tumor suppressor merlin depends on its ability to bind paxillin LD3 and associate with ???21 integrin and actin at the plasma membrane Stability of the tumor suppressor merlin depends on its ability to bind paxillin LD3 and associate with ???21 integrin and actin at the plasma membrane Stability of the tumor suppressor merlin depends on its ability to bind paxillin LD3 and associate with ???21 integrin and actin at the plasma membrane [J] . Marga Bott, Sandra Geden, Cristina Fernandez-Valle, Biology Open . 2012,第10期

机译：抑癌蛋白梅林的稳定性取决于其结合paxillin LD3并与质膜上的21整联蛋白和肌动蛋白结合的能力抑癌蛋白梅林的稳定性取决于其与paxillin LD3结合并与21整联蛋白结合的能力。抑制蛋白merlin的稳定性取决于其结合paxillin LD3并与质膜上的21整合素和肌动蛋白结合的能力。
4. Oncogenes and tumor suppressor genes in murine tumors induced by neutron- or gamma-irradiation in utero [C] . Sara Antal, K. Lumniczky, J. Palfalvi, International Symposium of Radiation and Homeostasis . 2002

机译：子宫中子或γ-辐照诱导的鼠肿瘤中的癌肠和肿瘤抑制基因
5. Walleye retroviral cyclins phosphorylate pRb tumor suppressor and the walleye dermal sarcoma retrovirus cyclin and G2/M cyclins repress transcription of p14ARF tumor suppressor through interaction with TBX2, possibly contributing to tumorigenesis. [D] . Kim, Sang-Woo. 2004

机译：角膜白斑逆转录病毒细胞周期蛋白使pRb肿瘤抑制蛋白磷酸化，而角膜皮肉瘤逆转录病毒细胞周期蛋白和G2 / M细胞周期蛋白通过与TBX2相互作用抑制p14ARF肿瘤抑制因子的转录，可能有助于肿瘤发生。
6. Micromanaging a large tumor suppressor [O] . Yanmei Li, David E. Spaner 2012

机译：微处理大型肿瘤抑制物
7. Tumor Suppressor Mutations and Growth Factor Signaling in the Pathogenesis of NF1-Associated Peripheral Nerve Sheath Tumors. I. The Role of Tumor Suppressor Mutations [O] . Steven L. Carroll, Mark S. Stonecypher 2004

机译：肿瘤抑制突变和生长因子信号在NF1相关周围神经鞘瘤的发病机制中。 I.肿瘤抑制突变的作用
8. SIRT3 is a Mitochondrial Tumor Suppressor and Genetic Loss Results in a Murine Model for ER/PR-Positive Mammary Tumors Connecting Metabolism and Carcinogenesis Mitochondrial Tumor Suppressor. Revision [R] . Freeman, M 2013

机译：sIRT3是线粒体肿瘤抑制因子和遗传损失导致小鼠模型的ER / pR阳性乳腺肿瘤连接代谢和致癌线粒体肿瘤抑制因子。调整

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