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首页> 外文期刊>Cell cycle >Common fragile sites nested at the interfaces of early and late-replicating chromosome bands: cis acting components of the G2/M checkpoint?
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Common fragile sites nested at the interfaces of early and late-replicating chromosome bands: cis acting components of the G2/M checkpoint?

机译：常见的脆弱位点嵌套在早期和晚期复制染色体带的界面上：G2 / M检查点的顺式作用成分？

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摘要

Common fragile sites (CFS) are evolutionary conserved loci where damage appears recurrently upon treatments perturbing DNA synthesis. Although long studied, the mechanisms underlying CFS fragility are still incompletely understood and CFS function is unknown. We have mapped most of them at the junction of chromosomal bands replicating at different times in S phase, indicating that specific replication programs take place at CFS. In good agreement with this finding, we obtained results suggesting that CFS remain incompletely replicated up to late G(2), even in cells that went unperturbed through S phase. The recent demonstration that the function of ATR and its downstream targets are crucial to CFS stability may thereby indicate that mitotic onset is delayed until completion of their replication. Altogether, available results now suggest that CFS constitute integral "cis" components of the G(2)-M checkpoint.
机译：常见的脆弱位点（CFS）是进化保守的基因座，在这种破坏中，扰动DNA合成的处理会反复出现损伤。尽管经过了长期的研究，但CFS脆弱性的潜在机制仍未完全了解，CFS的功能尚不清楚。我们已经将它们中的大多数映射到了在S期不同时间复制的染色体带的交界处，这表明特定的复制程序发生在CFS。与这一发现很好地吻合，我们获得的结果表明，即使在S期不受干扰的细胞中，CFS仍可以不完全复制直至G（2）晚期。最近的证明ATR及其下游靶标对CFS稳定性至关重要的最新证明可能表明有丝分裂的发生被延迟到复制完成之前。总的来说，现在可获得的结果表明CFS构成了G（2）-M检查点的整体“顺式”成分。

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