Negative feedbacks in normal cell growth and their suppression in tumorigenesis.

van-Staveren WC; Detours V; Dumont JE; Maenhaut C

首页> 外文期刊>Cell cycle >Negative feedbacks in normal cell growth and their suppression in tumorigenesis.

【24h】

Negative feedbacks in normal cell growth and their suppression in tumorigenesis.

机译：正常细胞生长中的负反馈及其在肿瘤发生中的抑制作用。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A human is composed of the order of 10 cells. Most of them result from many divisions. Considering that only one in three individuals develop a cancer, any cell has an extremely low probability to result in a cancer. This low probability is explained by the fact that different alterations must be accumulated in order to escape from normal growth control: self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis.We have shown that, in addition, the inactivation of multiple negative feedbacks, specific for activated signal transduction pathway, might also contribute to tumorigenesis.

机译：一个人由10个细胞组成。它们大多数来自许多部门。考虑到只有三分之一的人会患上癌症，因此任何细胞发生癌症的可能性极低。这种低概率的解释是，必须积累不同的变化才能脱离正常的生长控制：生长信号的自给自足，对生长抑制信号的不敏感性，细胞凋亡的逃逸，无限的复制潜力，持续的血管生成和组织入侵和转移。我们已经证明，此外，激活信号转导途径特异的多个负反馈的失活也可能有助于肿瘤的发生。

著录项

来源
《Cell cycle》 |2006年第6期|共2页
作者
van-Staveren WC; Detours V; Dumont JE; Maenhaut C;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Cell Proliferation; Cell Transformation; Neoplastic; Feedback; Biochemical; 细胞转化; 肿瘤; 基因表达调控; 肿瘤; 肿瘤; 信号传递;

机译：Cell Proliferation;Cell Transformation;Neoplastic;Feedback;Biochemical;细胞转化;肿瘤;基因表达调控;肿瘤;肿瘤;信号传递;

相似文献

外文文献
中文文献
专利

1. Negative feedbacks in normal cell growth and their suppression in tumorigenesis. [J] . van-Staveren WC, Detours V, Dumont JE, Cell cycle . 2006,第6期

机译：正常细胞生长中的负反馈及其在肿瘤发生中的抑制作用。
2. The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis. [J] . Kress TR, Cannell IG, Brenkman AB, Molecular cell . 2011,第4期

机译：MK5 / Prak激酶和MyC形成阴性反馈回路，在结肠直肠肿瘤内发生中断。
3. The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis. [J] . Kress TR, Cannell IG, Brenkman AB, Molecular cell . 2011,第4期

机译：MK5 / Prak激酶和MyC形成阴性反馈回路，在结肠直肠肿瘤内发生中断。
4. Negative growth regulation of SK-N-MC cells by bFGF defines a growth factor-sensitive point in G_2 [C] . Veronique A.J. Smits, Maartje A. van Peer, Marieke A.G. Essers, NATO Advanced Study Institute on Molecular Mechanisms of Signal Transduction . 2000

机译：BFGF的SK-N-MC细胞的负生长调节在G_2中定义了生长因子敏感点
5. Multi Negative Feedback Loops and Nonlinear Time-Delays in a Mathematical Model of Bone Morphogenetic Protein (BMP) Signaling in Vascular Endothelial Cells. [D] . Nia, Anna Mohtasham. 2015

机译：血管内皮细胞骨形态发生蛋白（BMP）信号传递数学模型中的多个负反馈回路和非线性时滞。
6. Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis. [O] . N Sheibani, W A Frazier 1995

机译：转化的内皮细胞中血小板反应蛋白1的表达可恢复正常表型并抑制其肿瘤发生。
7. Gene expression in human thyrocytes and autonomous adenomas reveals suppression of negative feedbacks in tumorigenesis. [O] . Van Staveren, Wilma, Solís, David Weiss, Delys, Laurent, 2006

机译：人甲状腺细胞和自主腺瘤中的基因表达揭示了肿瘤发生中负反馈的抑制作用。

Negative feedbacks in normal cell growth and their suppression in tumorigenesis.

摘要

著录项

相似文献

相关主题

期刊订阅