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首页> 外文期刊>Cell cycle >Grasses like mammals? Redundancy and compensatory regulation within the retinoblastoma protein family.
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Grasses like mammals? Redundancy and compensatory regulation within the retinoblastoma protein family.

机译：像哺乳动物的草？视网膜母细胞瘤蛋白家族中的冗余和补偿性调节。

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摘要

The retinoblastoma (RB) protein family plays a conserved and inhibitory role in cell cycle progression in higher eukaryotes. In mammals, this family includes, in addition to RB, the related (RBR) proteins p107 and p130, which appear to have both specific and redundant functions compared to those of the prototypical RB protein. Whereas most plant species seem to possess only one RBR gene, a recent study has shown that in maize there are two types of distinctly regulated RBR proteins, RBR1 and RBR3. Expression of RBR3 RNA is controlled by the RBR1-E2F pathway, and it is upregulated upon inhibition of RBR1 activity by the wheat dwarf virus RepA protein in tissue culture, indicating the presence of a specific compensatory mechanism sustaining high pocket protein activity. Database mining and phylogenetic analyses suggest the presence of two distinct RBR genes to be a unique feature of grasses among plants, which might help to explain their recalcitrance to genetic transformation.
机译：视网膜母细胞瘤（RB）蛋白家族在高等真核生物的细胞周期进程中起着保守和抑制作用。在哺乳动物中，该家族除RB外还包括相关的（RBR）蛋白p107和p130，与原型RB蛋白相比，它们具有特定的功能和多余的功能。尽管大多数植物物种似乎只具有一个RBR基因，但最近的一项研究表明，玉米中有两种类型的RBR蛋白受到明显调节，即RBR1和RBR3。 RBR3 RNA的表达受RBR1-E2F途径控制，在组织培养中小麦矮化病毒RepA蛋白抑制RBR1活性后，RBR3 RNA的表达上调，表明存在维持高袋装蛋白活性的特定补偿机制。数据库挖掘和系统发育分析表明，两个不同的RBR基因的存在是植物中草的独特特征，这可能有助于解释它们对遗传转化的顽固性。

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