The association of Tap42 phosphatase complexes with TORC1: another level of regulation in Tor signaling.

Di-Como CJ; Jiang Y

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The association of Tap42 phosphatase complexes with TORC1: another level of regulation in Tor signaling.

机译：Tap42磷酸酶复合物与TORC1的关联：Tor信号传导的另一个调控水平。

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In the budding yeast Saccharomyces cerevisiae, rapamycin has been known to induce a rapid dephosphorylation of many downstream targets of Tor. The key components mediating this dephosphorylation process are the Tap42-associated phosphatases, which become active upon rapamycin treatment. However, the mechanism by which rapamycin rapidly activates phosphatases is unclear. A recent report has provided evidence demonstrating a physical association of the Tap42-phosphatase complexes with TORC1, which is sensitive to rapamycin treatment or nutrient starvation. This association adds another level of regulation in Tor signaling, and explains why rapamycin or nutrient availability is able to initiate a rapid and robust response in the cell.

机译：在出芽的酿酒酵母中，已知雷帕霉素可诱导Tor的许多下游靶标快速脱磷酸。介导该去磷酸化过程的关键成分是Tap42相关的磷酸酶，该酶在雷帕霉素治疗后变得活跃。但是，雷帕霉素快速激活磷酸酶的机制尚不清楚。最近的一份报告提供了证据，证明Tap42磷酸酶复合物与TORC1的物理联系，TORC1对雷帕霉素治疗或营养缺乏很敏感。这种联系增加了Tor信号转导的另一个调控水平，并解释了雷帕霉素或营养素利用为何能够在细胞中引发快速而稳定的反应的原因。

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来源
《Cell cycle》 |2006年第23期|共4页
作者
Di-Como CJ; Jiang Y;
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正文语种 eng
中图分类细胞生物学;
关键词
1-Phosphatidylinositol 3-Kinase; Phosphotransferases (Alcohol Group Acceptor); 1-磷脂酰肌醇3-激酶; 磷酸转移酶类(醇族体); 酵母菌; 酿酒;

机译：1-Phosphatidylinositol 3-Kinase;Phosphotransferases (Alcohol Group Acceptor);1-磷脂酰肌醇3-激酶;磷酸转移酶类(醇族体);酵母菌;酿酒;

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专利

1. The association of Tap42 phosphatase complexes with TORC1: another level of regulation in Tor signaling. [J] . Di-Como CJ, Jiang Y Cell cycle . 2006,第23期

机译：Tap42磷酸酶复合物与TORC1的关联：Tor信号传导的另一个调控水平。
2. Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. [J] . Pan Y, Schroeder EA, Ocampo A, Cell metabolism . 2011,第6期

机译：通过自适应线粒体ROS信号由TORC1调节酵母的时间寿命。
3. The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe [J] . Nobuyasu Ikai, Norihiko Nakazawa, Takeshi Hayashi, Open Biology . 2011,第3期

机译：Tor2（TORC1）和Tor1（TORC2）激酶在粟酒裂殖酵母中的生长，细胞周期和分离酶介导的有丝分裂的反向但协调的作用
4. Mass Spectrometry Study of mTOR Phosphorylation in TORC1 and TORC2 Complexes [C] . Stone D.-H. Shi, Zhihua Tao, Shaoxian Sun, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：MTOR磷酸化在TORC1和TORC2复合物中的质谱研究
5. Membrane protein complexes involved in thrombospondin-1 regulation of nitric oxide signaling. [D] . Green, Toni. 2013

机译：膜蛋白复合物参与thrombospondin-1对一氧化氮信号的调节。
6. Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. [O] . Y Jiang, J R Broach 1999

机译：Tor蛋白和蛋白磷酸酶2A在控制酵母细胞生长中相互调节Tap42。
7. The Association of Tap42-Phosphatase Complexes with TORC1 — Another Level of Regulation in Tor Signaling [O] . Charles J Di Como, Yu Jiang 2006

机译：TATC1的TAP42-磷酸酶复合物的关联 - TOR信号传导中的另一个调节水平
8. Smad Acetylation: A New Level of Regulation in TGF-Beta Signaling. [R] . Tu, A. W. 2007

机译：smad乙酰化：TGF-β信号调节的新水平。

The association of Tap42 phosphatase complexes with TORC1: another level of regulation in Tor signaling.

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