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首页> 外文期刊>Cell cycle >Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase.
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Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase.

机译：在不受干扰的S期，ATR / Chk1途径维持正常的复制叉进展的证据。

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摘要

If cells are treated with DNA damaging agents or inhibitors that interfere with ongoing DNA replication, the intra-S and S/M checkpoints delay progression through S phase and mitotic entry, respectively, to allow time for DNA repair and replication restart. In vertebrates, these checkpoint responses to replication blocks are largely mediated by the sensor kinase ATR and its major downstream effector kinase Chk1. Increasing evidence suggests that the ATR pathway is also vital in the absence of exogenous stresses, i.e., during "unperturbed" replication. Both ATR and Chk1 are essential proteins in vertebrates, and lack of components of the ATR/Chk1 pathway can result in impaired replication and spontaneous DNA damage. Here we give an overview of how the ATR/Chk1 pathway responds to exogenously blocked replication and then describe evidence for roles of this pathway during replication in an unperturbed S phase.
机译：如果用干扰DNA持续复制的DNA破坏剂或抑制剂处理细胞，则S和S / M内检查点将分别延迟S期和有丝分裂进入的进程，从而有时间进行DNA修复和复制重启。在脊椎动物中，这些对复制阻滞的检查点反应主要由传感器激酶ATR及其主要的下游效应子激酶Chk1介导。越来越多的证据表明，在没有外源压力的情况下，即在“不受干扰”的复制过程中，ATR途径也至关重要。 ATR和Chk1都是脊椎动物中的必需蛋白，缺少ATR / Chk1途径的成分会导致复制受损和自发性DNA损伤。在这里，我们概述了ATR / Chk1途径如何响应外源性复制，然后描述了在不受干扰的S期复制过程中该途径的作用的证据。

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