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首页> 外文期刊>Cell cycle >ASPP2: a gene that controls life and death in vivo.
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ASPP2: a gene that controls life and death in vivo.

机译：ASPP2：一种在体内控制生命和死亡的基因。

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The fundamental role of apoptosis in tumor prevention and the important role of p53 in this process are now universally recognized. Recently, several families of p53-binding proteins have been shown to influence p53's decision to direct the cells either into the apoptotic pathway or in cell cycle arrest. Among them, the ASPP family specifically regulate p53-dependent apoptosis. Its member ASPP2 was discovered more than 10 years ago as a binding partner of p53 and its role as a positive regulator of p53 mediated apoptosis has been clearly established in vitro. However, its physiological importance in vivo has just emerged through the generation and characterisation of the ASPP2-deficient mice. We now know that ASPP2 is a haploinsufficient tumor suppressor and an important activator of p53 during mouse development and tumor suppression in vivo. ASPP2 might be a novel target for future cancer therapy.
机译：细胞凋亡在肿瘤预防中的基本作用以及p53在这一过程中的重要作用现已得到普遍认可。最近，已经显示了几个p53结合蛋白家族会影响p53决定将细胞定向进入凋亡途径或细胞周期阻滞的决定。其中，ASPP家族特异性调节p53依赖性细胞凋亡。它的成员ASPP2于10年前被发现是p53的结合伴侣，并且在体外已明确确立了其作为p53介导的细胞凋亡的正调节剂的作用。但是，它在体内的生理重要性刚刚通过ASPP2缺陷小鼠的产生和鉴定出现。我们现在知道，ASPP2在小鼠发育和体内肿瘤抑制过程中是单倍体不足的肿瘤抑制剂和p53的重要激活剂。 ASPP2可能是未来癌症治疗的新靶标。

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