Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.

Popov N; Herold S; Llamazares M; Schulein C; Eilers M

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Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.

机译：Fbw7和Usp28调节myc蛋白稳定性以响应DNA损伤。

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The cellular levels of the Myc oncoprotein are critical determinants of cell proliferation, cell growth and apoptosis and are tightly regulated by external growth factors. Levels of Myc oncoprotein also decline in response to intracellular stress signals such as DNA damage. We show here that this decline is in part due to proteasomal degradation and that it is mediated by the Fbw7 ubiquitin ligase. We have shown previously that the ubiquitin-specific protease Usp28, binds to the nucleoplasmic isoform of Fbw7, Fbw7alpha, and counteracts its function in mammalian cells. Usp28 dissociates from Fbw7alpha in response to UV irradiation, providing a mechanism how Fbw7-mediated degradation of Myc is enhanced upon DNA damage. Our data extend previous observations that link Myc function to the cellular response to DNA damage.

机译：Myc癌蛋白的细胞水平是细胞增殖，细胞生长和凋亡的关键决定因素，并受到外部生长因子的严格调控。 Myc癌蛋白的水平也会响应细胞内应激信号（例如DNA损伤）而下降。我们在这里表明，这种下降部分是由于蛋白酶体降解，并且它是由Fbw7泛素连接酶介导的。以前我们已经表明，泛素特异性蛋白酶Usp28与Fbw7，Fbw7alpha的核质同工型结合，并抵消其在哺乳动物细胞中的功能。 Usp28响应紫外线照射而从Fbw7alpha上解离，提供了一种机制，即在DNA损伤后如何增强Fbw7介导的Myc降解。我们的数据扩展了以前的观察结果，这些观察结果将Myc功能与细胞对DNA损伤的反应联系起来。

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《Cell cycle》 |2007年第19期|共5页
作者
Popov N; Herold S; Llamazares M; Schulein C; Eilers M;
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正文语种 eng
中图分类细胞生物学;
关键词
Animals; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Line; DNA Damage; 动物; 脱噬作用; 细胞周期; 细胞周期蛋白质类; 细胞系; DNA损伤; 原癌基因蛋白质C-MYC类;

机译：Animals;Apoptosis;Cell Cycle;Cell Cycle Proteins;Cell Line;DNA Damage;动物;脱噬作用;细胞周期;细胞周期蛋白质类;细胞系;DNA损伤;原癌基因蛋白质C-MYC类;

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专利

1. Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. [J] . Popov N, Herold S, Llamazares M, Cell cycle . 2007,第19期

机译：Fbw7和Usp28调节myc蛋白稳定性以响应DNA损伤。
2. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation [J] . Welcker M, Orian A, Jin JP, Proceedings of the National Academy of Sciences of the United States of America . 2004,第24期

机译：Fbw7肿瘤抑制因子调节糖原合酶激酶3磷酸化依赖性c-Myc蛋白降解
3. 27-Hydroxycholesterol increases Myc protein stability via suppressing PP2A, SCP1 and FBW7 transcription in MCF-7 breast cancer cells [J] . Ma Li-Ming, Liang Zi-Rui, Zhou Ke-Ren, Biochemical and Biophysical Research Communications . 2016,第3期

机译：27-羟基胆固醇通过抑制MCF-7乳腺癌细胞中的PP2A，SCP1和FBW7转录增加Myc蛋白的稳定性
4. Biophysical Studies of the Structure, Stability, and Ligand Binding Properties of G-Quadruplex DNA: Thoughts and Comparisons of the K-ras, c-MYC, and Bcl-2 Oncogene Promoter Sequence Quadruplexes [C] . Jamie M. Dettler, Edwin A. Lewis Symposium on frontiers in nucleic acids . 2011

机译：G-Quadreplex DNA的结构，稳定性和配体结合性能的生物物理研究：K-RAS，C-MYC和BCL-2癌基因促进剂序列四边形思想和比较
5. Functional analysis of p53 N-terminal phosphorylation and C-terminal multiple posttranslational modifications in regulating p53 responses to DNA damage. [D] . Feng, Lijin. 2006

机译：p53 N末端磷酸化和C末端多个翻译后修饰在调节p53对DNA损伤的反应中的功能分析。
6. The F-box protein FBXL16 up-regulates the stability of C-MYC oncoprotein by antagonizing the activity of the F-box protein FBW7 [O] . Marion Morel, Krushangi N. Shah, Weiwen Long 2020

机译：F-Box蛋白FBXL16通过拮抗F箱蛋白FBW7的活性来调节C-Myc癌蛋白的稳定性
7. Fbw7 and Usp28 Regulate Myc Protein Stability in Response to DNA Damage [O] . Nikita Popov, Steffi Herold, Maria Llamazares, 2007

机译：FBW7和USP28响应DNA损伤调节Myc蛋白稳定性
8. Protein That Modulates The Stability of Transcriptional Regulatory Complexes Regulating Nuclear Hormone Receptor Activity, DNA Encoding Same and Antibodies Thereto. [R] . Basach, R. S., Zhang, X. M. 2001

机译：蛋白质调节转录调节复合物的稳定性调节核激素受体活性，编码相同的DNa和抗体。

Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.

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