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首页> 外文期刊>Cell cycle >Combinatorial microRNAs: working together to make a difference.
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Combinatorial microRNAs: working together to make a difference.

机译：组合式microRNA：共同发挥作用。

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摘要

MicroRNAs regulate gene networks and therefore are inherently complex. MicroRNAs themselves function in networks of other microRNAs, some of which are co-expressed from the same locus. To better understand the interplay among microRNAs that underlies their functions, we examined the potential of combinatorial effects of endogenously and exogenously co-expressed microRNAs. In this review, we first distill the similarities and differences between three microRNA families that function in cell division, miR-16, miR-34a and miR-106b, with emphasis on their exquisite phenotypic diversity. Given that the microRNAs affect cell cycle progression via distinct targets, we tested for phenotypic synergism among them. Furthermore, we investigate target regulation by individual and pooled microRNAs to gain insight into interactions among microRNAs co-expressed from the same chromosomal locus. The ability of microRNAs to modulate multiple genes within a molecular pathway engenders a novel way of thinking about targeting pathways: instead of a one-inhibitor-one-target model, multiple components in a pathway can be modulated by a microRNA resulting in a potent yet reversible inhibition of the pathway. To fully realize this potential, we need to understand how microRNAs function singly and in concert with each other.
机译：MicroRNA调控基因网络，因此固有地是复杂的。 MicroRNA本身在其他MicroRNA的网络中起作用，其中某些是在同一位点共表达的。为了更好地了解构成其功能的microRNA之间的相互作用，我们检查了内源性和外源性共表达的microRNA组合作用的潜力。在这篇综述中，我们首先提炼了在细胞分裂中起作用的三个microRNA家族之间的相似性和差异，miR-16，miR-34a和miR-106b，并着重于它们的精美表型多样性。鉴于microRNA通过不同的靶标影响细胞周期进程，我们测试了它们之间的表型协同作用。此外，我们研究了单个和汇集的microRNA的靶标调控作用，以洞察从同一染色体基因座共表达的microRNA之间的相互作用。 microRNA调节分子途径内多个基因的能力引发了一​​种新的靶向途径的思考方式：microRNA可以调节途径中的多种成分，而不是单一抑制剂一靶点的模型，从而产生了强大而又有效的途径。可逆抑制该途径。为了充分发挥这种潜力，我们需要了解微RNA如何单独发挥作用，以及彼此之间如何协同作用。

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