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microRNAs: novel components in a muscle gene regulatory network.

机译:microRNA:肌肉基因调控网络中的新型成分。

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摘要

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level via translational inhibition or mRNA degradation. Emerging evidence supports that miRNAs play critical roles in skeletal and cardiac muscle, as both muscle-specific and non-muscle-specific miRNAs are required for the development and differentiation of these tissues. Their interactions with myogenic factors also integrate miRNAs into a complex regulatory network underlying myogenesis. Furthermore, their dysregulation and associated pathologies suggest that miRNA-based therapies may be effective in treating muscle-related disorders.
机译:MicroRNA(miRNA)是小的非编码RNA,可通过翻译抑制或mRNA降解在转录后水平调节基因表达。新兴证据支持miRNA在骨骼肌和心肌中发挥关键作用,因为肌肉特异性和非肌肉特异性miRNA都是这些组织发育和分化所必需的。它们与肌源性因子的相互作用也将miRNA整合到了一个基础的肌生成的复杂调控网络中。此外,它们的失调和相关病理表明基于miRNA的疗法可能有效治疗肌肉相关疾病。

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