Dancing with p53: The role of p38MAPK in mitosis of p53-deficient tetraploid cells.

Shieh SY

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Dancing with p53: The role of p38MAPK in mitosis of p53-deficient tetraploid cells.

机译：与p53跳舞：p38MAPK在缺乏p53的四倍体细胞有丝分裂中的作用。

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p38MAPK, a member of the mitogen-activated protein kinase superfamily, plays a role in the stress response induced by ultraviolet (UV) radiation, osmotic shock, and proinflamma-tory stimuli such as lipopolysaccharide. Of particular interest is its involvement in mitotic progression. In the Xenopus oocyte, p38 is required for meiotic transition from G2 to M and for metaphase arrest.12 p38 has also been shown to be essential for the spindle assembly checkpoint (SAC) in somatic cells such as NIH3T3 and HeLa cells.

机译：p38MAPK是有丝分裂原激活的蛋白激酶超家族的成员，在紫外线（UV），渗透压休克和促炎性刺激（如脂多糖）诱导的应激反应中发挥作用。特别令人感兴趣的是其参与有丝分裂进程。在非洲爪蟾卵母细胞中，p38是从G2到M的减数分裂过渡和中期停滞所必需的。12p38也已显示对于体细胞（如NIH3T3和HeLa细胞）中的纺锤体组装检查点（SAC）是必不可少的。

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《Cell cycle》 |2010年第14期|共1页
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Shieh SY;
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中图分类细胞生物学;
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1. 鼻咽癌中p53蛋白积聚对瘤细胞有丝分裂和凋亡的影响 [J] . 钟碧玲, 宗永生癌症（英文版） . 2000,第005期
2. Dancing with p53: The role of p38MAPK in mitosis of p53-deficient tetraploid cells. [J] . Shieh SY Cell cycle . 2010,第14期

机译：与p53跳舞：p38MAPK在缺乏p53的四倍体细胞有丝分裂中的作用。
3. Loss of histone deacetylase 4 causes segregation defects during mitosis of p53-deficient human tumor cells. [J] . Cadot B, Brunetti M, Coppari S Cancer research: The official organ of the American Association for Cancer Research, Inc . 2009,第15期

机译：组蛋白脱乙酰基酶4的损失会导致p53缺陷型人类肿瘤细胞有丝分裂期间的分离缺陷。
4. Role of Bax/Bcl-2 family members in green tea polyphenol induced necroptosis of p53-deficient Hep3B cells. [J] . Weiping Lin, Sun Tongyi Tumour biology : . 2014,第8期

机译：Bax / Bcl-2家族成员在绿茶多酚诱导的p53缺陷Hep3B细胞坏死性坏死中的作用。
5. Induction of apoptosis in p53-deficient L1210cells by an I-К-B-α-inhibitor (Bay 11-7085)via a NF-К-B-independent mechanism [C] . Ann H. Cory, Joseph G. Cory International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2005

机译：通过NF-к-b-β-抑制剂（Bay 11-7085）通过NF-к-B-B-B-B-B-B-β-β-抑制剂诱导P53缺陷L1210Cells的凋亡
6. Genetic or HPV-Induced CENP-E Loss Promotes Chromosomal Instability and Protects Against Tumor Growth in p53-Deficient Cancers [D] . Funk, Laura C. 2020

机译：遗传或HPV诱导的CENP-E损失促进染色体不稳定性并防止P53缺陷癌症的肿瘤生长
7. Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells [O] . Deborah Wilsker, Jon H. Chung, Fred Bunz 2012

机译：Chk1抑制p53缺陷癌细胞中有丝分裂和四倍体化的旁路
8. p53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cells. [O] . Qiyi Yi, Xiaoyu Zhao, Yun Huang, 2011

机译：p53依赖性中心体聚类可防止四倍体细胞中的多极有丝分裂。
9. P53-Deficient Mouse as a Breast Cancer Model [R] . Donehower, L. A. 1998

机译：p53缺陷小鼠作为乳腺癌模型

Dancing with p53: The role of p38MAPK in mitosis of p53-deficient tetraploid cells.

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