Rarity of AKT1 and AKT3 E17K mutations in squamous cell carcinoma of lung.

Do H; Salemi R; Murone C; Mitchell PL; Dobrovic A

首页> 外文期刊>Cell cycle >Rarity of AKT1 and AKT3 E17K mutations in squamous cell carcinoma of lung.

【24h】

Rarity of AKT1 and AKT3 E17K mutations in squamous cell carcinoma of lung.

机译：肺鳞状细胞癌中AKT1和AKT3 E17K突变的罕见性。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The recent discovery of a recurrent gain-of-function mutation, E17K, in the pleck-strin homology domain of the AKTl gene in breast, ovarian and colorectal tumors has caused considerable interest because AKTl is a critical mediator of a signaling pathway controlling cell proliferation, survival and angiogenesis.1'2 The E17K mutation results in constitutive activation of AKTl serine/threonine kinase activity by localization of AKTl to the plasma membrane in a PI3K-dependent manner.1 Interestingly, an analogous activating E17K mutation in the AKT3 gene has been reported in melanoma tumors and melanoma cell lines.

机译：乳腺，卵巢和大肠肿瘤中AKT1基因的斑点-Strin同源结构域中复发性功能获得性突变E17K的最新发现引起了人们的极大兴趣，因为AKT1是控制细胞增殖的信号传导途径的关键介体，存活和血管生成。1'2E17K突变导致AKT1丝氨酸/苏氨酸激酶活性以PI3K依赖性方式定位于质膜，从而组成性激活AKT1丝氨酸/苏氨酸激酶活性。1有趣的是，AKT3基因中类似的激活E17K突变具有在黑色素瘤肿瘤和黑色素瘤细胞系中已有报道。

著录项

来源
《Cell cycle》 |2010年第21期|共2页
作者
Do H; Salemi R; Murone C; Mitchell PL; Dobrovic A;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词

相似文献

外文文献
中文文献
专利

1. Rarity of AKT1 and AKT3 E17K mutations in squamous cell carcinoma of lung. [J] . Do H, Salemi R, Murone C, Cell cycle . 2010,第21期

机译：肺鳞状细胞癌中AKT1和AKT3 E17K突变的罕见性。
2. Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations [J] . J Lauring, D P Cosgrove, S Fontana, Oncogene . 2010,第16期

机译：敲除人乳腺上皮细胞中的AKT1 E17K突变不能概括致癌的PIK3CA突变
3. Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas. [J] . Soung YH, Lee JW, Nam SW, Oncology: International Journal of Cancer Research and Treatment . 2006,第4期

机译：常见人类癌症中AKT1，AKT2和AKT3基因的突变分析。
4. Prediction of tumour mutational burden of squamous cell carcinoma using histopathology images of surgical specimens [C] . Salma Dammak, Matthew Cecchini, Katherina Baranova, Conference on Medical Imaging: Digital Pathology;Society of Photo-Optical Instrumentation Engineers . 2020

机译：利用手术标本的组织病理学图像预测鳞状细胞癌的肿瘤突变负担
5. Identification of Novel Candidate Tumor Suppressor Genes at 11q and 15q for Esophageal Squamous Cell Carcinoma and Nasopharyngeal Carcinoma via Integrative Cancer Epigenetics and Genomics. [D] . Li, Jisheng. 2010

机译：通过综合癌症表观遗传学和基因组学鉴定食管鳞状细胞癌和鼻咽癌的11q和15q新型候选肿瘤抑制基因。
6. Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations [O] . Josh Lauring, David P. Cosgrove, Stefani Fontana, -1

机译：敲入人乳腺上皮细胞中的AKT1 E17K突变并未重新延长致癌纤维素突变
7. Patterns of p53 mutations in squamous cell carcinoma of the lung. Acquisition at a relatively early age. [O] . Zheng J., Shu Q., Li Z. H., 100

机译：肺鳞状细胞癌中p53突变的模式。在相对较早的年龄进行采集。

Rarity of AKT1 and AKT3 E17K mutations in squamous cell carcinoma of lung.

摘要

著录项

相似文献

相关主题

期刊订阅